{"id":"aac0b379-78bc-5432-93eb-d6080d17d740","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-mg24","predicate":"increases","statement":"Later nighttime conservation did not fully offset earlier loss; net 24-hour urinary excretion increased by 0.16 mmol.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"be7376cb-1f73-51e1-82c8-aaa1d47ea3c8","mechanism_event_label":"Later compensation reduced, but did not erase, the measured daily loss.","subject":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"object":{"id":"a298b414-0e07-568d-a469-d8aa3e8b8c14","slug":"urinary-magnesium-excretion","display_name":"Urinary magnesium excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"be7376cb-1f73-51e1-82c8-aaa1d47ea3c8","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-mg24-event","event_type":"observed_relationship","label":"Later compensation reduced, but did not erase, the measured daily loss.","description":"Later nighttime conservation did not fully offset earlier loss; net 24-hour urinary excretion increased by 0.16 mmol.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a298b414-0e07-568d-a469-d8aa3e8b8c14","slug":"urinary-magnesium-excretion","display_name":"Urinary magnesium excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"17 adults; controlled diet; two 3 mg/kg lean-body-mass doses on day two of a before/after metabolic-ward trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Two-day urinary balance is not total body mineral balance or a long-term deficiency diagnosis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Later compensation reduced, but did not erase, the measured daily loss.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effect of caffeine on circadian excretion of urinary calcium and magnesium. · 1994 · https://pubmed.ncbi.nlm.nih.gov/7836625/ · DOI 10.1080/07315724.1994.10718436","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"80938970-e7eb-50c3-aa20-9c128334f8d4","evidence_kind":"source_excerpt","locator":"Lines 348-354","start_line":348,"end_line":354,"excerpt":"## caf-mg24\nLater compensation reduced, but did not erase, the measured daily loss.\nLater nighttime conservation did not fully offset earlier loss; net 24-hour urinary excretion increased by 0.16 mmol.\nModel: 17 adults; controlled diet; two 3 mg/kg lean-body-mass doses on day two of a before/after metabolic-ward trial.\nLimitations: Two-day urinary balance is not total body mineral balance or a long-term deficiency diagnosis.\nEvidence access: Primary abstract\nEffect of caffeine on circadian excretion of urinary calcium and magnesium. · 1994 · https://pubmed.ncbi.nlm.nih.gov/7836625/ · DOI 10.1080/07315724.1994.10718436","model_system":"17 adults; controlled diet; two 3 mg/kg lean-body-mass doses on day two of a before/after metabolic-ward trial.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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