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(2016). https://pubmed.ncbi.nlm.nih.gov/26893170/ DOI: 10.1186/s40360-016-0052-2","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma exposure","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fb0e464e-c74a-5da2-9756-9e72399108aa","evidence_kind":"source_excerpt","locator":"Lines 669-680","start_line":669,"end_line":680,"excerpt":"### melatonin-oral-peak\nMean time to peak concentration was about 41 minutes after the tested oral dose.\nCondition category: normal\nnutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Immediate-release blood exposure rises relatively quickly in this experiment.\norganism: Twelve healthy men\ntissue_or_cell_type: Plasma exposure\nexperimental_model: Oral versus intravenous crossover pharmacokinetics\nlimitations: Specific immediate-release preparation and study population. 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