{"id":"aa9d5e2e-e5b5-5497-8ed1-b9eb139786d7","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:renal-calcium-entry-supports-flow-k-secretion","predicate":"supports","statement":"Removing luminal Ca2+ or buffering intracellular Ca2+ suppressed flow-stimulated K secretion in microperfused rabbit CCDs.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"8ee1e4a9-9f12-5460-bc78-a2ff5c9a4e8a","mechanism_event_label":"Calcium entry and signaling are required for this flow-driven potassium output.","subject":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"object":{"id":"00c10917-2733-5c41-ad97-d2b51417e6dd","slug":"renal-potassium-secretion","display_name":"Distal renal potassium secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8ee1e4a9-9f12-5460-bc78-a2ff5c9a4e8a","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:renal-calcium-entry-supports-flow-k-secretion-event","event_type":"biochemical_relationship","label":"Calcium entry and signaling are required for this flow-driven potassium output.","description":"Removing luminal Ca2+ or buffering intracellular Ca2+ suppressed flow-stimulated K secretion in microperfused rabbit CCDs.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"causal-subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"00c10917-2733-5c41-ad97-d2b51417e6dd","slug":"renal-potassium-secretion","display_name":"Distal renal potassium secretion","entity_type_key":"cellular_process"},"role":"measured-target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"3774e390-948f-57ec-b2ee-052930a9ec6c","slug":"kcnma1","display_name":"Large-conductance calcium-activated potassium channel alpha subunit","entity_type_key":"protein"},"role":"BK-context","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"secreted-ion","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"9465acdc-1e9d-5e77-a954-e07dd8945385","slug":"luminal-flow","display_name":"Renal tubular luminal flow","entity_type_key":"cellular_process"},"role":"stimulus","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Local calcium availability permits flow-stimulated potassium secretion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Results; 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