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species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The transport cycle linked a cytosolic redox pool to mitochondrial machinery.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The malate-aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41704162/ · DOI 10.1111/febs.70461","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"397583dd-8daf-546b-83d9-64c8a6656505","evidence_kind":"source_excerpt","locator":"Lines 322-328","start_line":322,"end_line":328,"excerpt":"## l-aspartate-brown-shuttle-redox\nThe transport cycle linked a cytosolic redox pool to mitochondrial machinery.\nIsolated mouse brown-fat mitochondria reconstituted with cytosolic shuttle enzymes oxidized extramitochondrial NADH in a glutamate-dependent manner.\nModel: Mouse C57BL/6J brown-fat mitochondria and reconstituted enzyme system.\nLimitations: An isolated-organelle assay does not prove that oral aspartate increases thermogenesis.\nEvidence access: Primary full text\nThe malate-aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41704162/ · DOI 10.1111/febs.70461","model_system":"Mouse C57BL/6J brown-fat mitochondria and reconstituted enzyme system.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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