{"id":"aa58fcd7-a06e-590e-9766-9e35195f7a31","stable_key":"research:gpx2-loss-increases-gpx1-protein","predicate":"loss-increases-abundance","statement":"Gpx2 deletion increased intestinal GPX1 protein without a matching mRNA increase.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"literature_reviewed:direct_experimental","direction":"positive","is_public":true,"mechanism_event_id":"ab979f3e-6e2f-54bd-b622-13aae85bff1d","mechanism_event_label":"GPX1 protein rose as an incomplete compensatory response.","subject":{"id":"23c45f6d-8ff2-5a4e-8260-6a75613a8fac","slug":"gpx2","display_name":"GPX2","entity_type_key":"protein"},"object":{"id":"e79d035c-0c02-5c0e-ac8f-d7fdeb663fbd","slug":"gpx1","display_name":"GPX1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"ab979f3e-6e2f-54bd-b622-13aae85bff1d","stable_key":"research:gpx2-loss-increases-gpx1-protein","event_type":"compensation","label":"GPX1 protein rose as an incomplete compensatory response.","description":"Gpx2 deletion increased intestinal GPX1 protein without a matching mRNA increase.","status":"active","compartment":{"slug":"intestinal-epithelium","display_name":"Intestinal epithelium"},"participants":[{"entity":{"id":"23c45f6d-8ff2-5a4e-8260-6a75613a8fac","slug":"gpx2","display_name":"GPX2","entity_type_key":"protein"},"role":"perturbed-protein","stoichiometry":null,"state_label":"deleted","sequence_order":0,"notes":""},{"entity":{"id":"e79d035c-0c02-5c0e-ac8f-d7fdeb663fbd","slug":"gpx1","display_name":"GPX1","entity_type_key":"protein"},"role":"compensating-protein","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cell_type","value_text":"intestinal epithelium","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Gpx2 knockout","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Compensation did not erase the crypt phenotype.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"mouse","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ae37d6e8-b8bd-56e4-a424-b98383a2cea4","evidence_kind":"curated_literature_summary","locator":"lines 666-676","start_line":666,"end_line":676,"excerpt":"## gpx2-loss-increases-gpx1-protein\n\nGPX1 protein rose as an incomplete compensatory response.\n\nGpx2 deletion increased intestinal GPX1 protein without a matching mRNA increase.\n\nOrganism: mouse\nCell type: intestinal epithelium\nExperimental model: Gpx2 knockout\nLimitations: Compensation did not erase the crypt phenotype.\nPrimary reference: [Loss of GPx2 increases apoptosis, mitosis, and GPx1 expression in the intestine of mice](https://pubmed.ncbi.nlm.nih.gov/20828612/)","model_system":"Gpx2 knockout","directness":"author_interpretation","verification_status":"secondary_verified","notes":"Curated summary; inspect the linked primary papers for original methods and results.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f892f13-06ea-5199-a33c-a703f35c80ae","stable_key":"selenium-research-2026-09-17","title":"Selenium: literature corrections and mechanism additions","document_type":"curated_literature_review","citation_label":"Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually","file_path":"","sha256":"0b818b10c1c7120e5caf7f4d4019d7bd025d745692e424f515d3ef903c9ab7f3","revision_id":"80984e03-5f0f-5877-8094-afef7637444e","review_status":"secondary_verified","notes":"Secondary curated summaries of primary experiments, with explicit models and limitations. Not archived primary full text."}}],"relations":[],"conflicts":[],"corrections":[],"research":{"topic":"intestinal-homeostasis","plain_language":"GPX1 protein rose as an incomplete compensatory response.","evidence_scope":"direct_experimental","papers":[{"key":"florian-2010-gpx2-crypts","title":"Loss of GPx2 increases apoptosis, mitosis, and GPx1 expression in the intestine of mice","url":"https://pubmed.ncbi.nlm.nih.gov/20828612/","doi":"10.1016/j.freeradbiomed.2010.08.029","year":2010,"model":"Gpx2-knockout mice on defined selenium diets","summary":"Finds crypt apoptosis and increased GPX1 protein after GPX2 loss, with incomplete compensation."}]}}