{"id":"aa528d9a-29a4-51ae-83f2-36c411598723","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-mouse-microbial-thrombosis","predicate":"increases","statement":"Adding E. timonensis to defined microbial communities in gnotobiotic mice completed carnitine-to-TMA conversion, raised TMAO and enhanced thrombosis after arterial injury.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"294889df-2eb9-5c58-9e32-a0da4446df17","mechanism_event_label":"A microbial addition tested a downstream vascular consequence.","subject":{"id":"4ae3605e-f6eb-51bd-8564-8d1e37895437","slug":"e-timonensis","display_name":"Emergencia timonensis","entity_type_key":"cell_type"},"object":{"id":"1e494864-cb99-573f-a553-bbe58a3a9cc7","slug":"mouse-gnotobiotic-thrombosis","display_name":"Gnotobiotic mouse arterial-injury thrombosis potential","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"294889df-2eb9-5c58-9e32-a0da4446df17","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-mouse-microbial-thrombosis-event","event_type":"observed_relationship","label":"A microbial addition tested a downstream vascular consequence.","description":"Adding E. timonensis to defined microbial communities in gnotobiotic mice completed carnitine-to-TMA conversion, raised TMAO and enhanced thrombosis after arterial injury.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4ae3605e-f6eb-51bd-8564-8d1e37895437","slug":"e-timonensis","display_name":"Emergencia timonensis","entity_type_key":"cell_type"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1e494864-cb99-573f-a553-bbe58a3a9cc7","slug":"mouse-gnotobiotic-thrombosis","display_name":"Gnotobiotic mouse arterial-injury thrombosis potential","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e83c0395-55f1-5483-9710-9b9aa9767689","slug":"gamma-butyrobetaine","display_name":"gamma-Butyrobetaine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8b3c1617-bb80-5858-bde0-65e139efbc68","slug":"trimethylamine-n-oxide","display_name":"Trimethylamine N-oxide / TMAO","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Gnotobiotic mouse transplantation with defined communities.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a human clinical-event trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Carnitine collection; 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