{"id":"aa52892a-e5f0-5acb-af28-12ad02dd0c76","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-pept2-kidney","predicate":"knockout_increases","statement":"Deleting Pept2 increased renal clearance of injected carnosine about 18-fold and reduced fractional reabsorption.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5a266b42-5261-5379-9ac2-d512427db74f","mechanism_event_label":"Kidney peptide transport helps retain the molecule.","subject":{"id":"d36cda69-0855-55d3-be6a-d67c5bb1eb5b","slug":"mouse-slc15a2","display_name":"Mouse peptide transporter 2 / Slc15a2","entity_type_key":"protein"},"object":{"id":"63147004-84ca-5ca4-8932-326dc8e5973f","slug":"mouse-carnosine-renal-clearance","display_name":"Mouse renal clearance of exogenous carnosine","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5a266b42-5261-5379-9ac2-d512427db74f","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-pept2-kidney-event","event_type":"observed_relationship","label":"Kidney peptide transport helps retain the molecule.","description":"Deleting Pept2 increased renal clearance of injected carnosine about 18-fold and reduced fractional reabsorption.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d36cda69-0855-55d3-be6a-d67c5bb1eb5b","slug":"mouse-slc15a2","display_name":"Mouse peptide transporter 2 / Slc15a2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"63147004-84ca-5ca4-8932-326dc8e5973f","slug":"mouse-carnosine-renal-clearance","display_name":"Mouse renal clearance of exogenous carnosine","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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