{"id":"aa2c0eb3-135c-5952-a589-62a264bbc4e1","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-snackbar-hormones","predicate":"does_not_differentially_change_tested","statement":"GLP-1, GIP, tyrosine and phenylalanine responses were similar with aspartame and control snack bars.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"5f1e3aef-6400-5c1e-9e62-ab184e51ee4d","mechanism_event_label":"Receptor activity did not translate into a distinct measured response in this meal.","subject":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"object":{"id":"ef82e9f1-52d2-568a-825f-cb187726aa6c","slug":"human-aspartame-snackbar-incretins","display_name":"Human GLP-1/GIP response in aspartame snack-bar study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5f1e3aef-6400-5c1e-9e62-ab184e51ee4d","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-snackbar-hormones-event","event_type":"observed_relationship","label":"Receptor activity did not translate into a distinct measured response in this meal.","description":"GLP-1, GIP, tyrosine and phenylalanine responses were similar with aspartame and control snack bars.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ef82e9f1-52d2-568a-825f-cb187726aa6c","slug":"human-aspartame-snackbar-incretins","display_name":"Human GLP-1/GIP response in aspartame snack-bar study","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bcfef85f-831d-5439-ba51-1aef4b090441","slug":"l-tyrosine","display_name":"L-Tyrosine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"190407ad-0219-54b5-b05f-7c75f3895ca6","slug":"l-phenylalanine","display_name":"L-Phenylalanine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text and author-list correction","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same human crossover.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not comparable to isolated cells or susceptible-mouse feeding by dose or endpoint. Correction record: Publisher correction concerns author order, affiliations and citation; no experimental-result correction is stated. Correction PMID 25951455 inspected in full text. https://doi.org/10.1371/journal.pone.0126039","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Receptor activity did not translate into a distinct measured response in this meal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Aspartame sensitivity? A double blind randomised crossover study. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25786106/ · DOI 10.1371/journal.pone.0116212","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d4e85e0c-c637-51d7-8c1b-f1a60da46ef5","evidence_kind":"source_excerpt","locator":"Lines 330-336","start_line":330,"end_line":336,"excerpt":"## aspartame-snackbar-hormones\nReceptor activity did not translate into a distinct measured response in this meal.\nGLP-1, GIP, tyrosine and phenylalanine responses were similar with aspartame and control snack bars.\nModel: Same human crossover.\nLimitations: Not comparable to isolated cells or susceptible-mouse feeding by dose or endpoint. Correction record: Publisher correction concerns author order, affiliations and citation; no experimental-result correction is stated. Correction PMID 25951455 inspected in full text. https://doi.org/10.1371/journal.pone.0126039\nEvidence access: Primary full text and author-list correction\nAspartame sensitivity? A double blind randomised crossover study. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25786106/ · DOI 10.1371/journal.pone.0116212","model_system":"Same human crossover.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2bba7d36-993f-5ba7-acaf-2e4d573527ed","stable_key":"import-b428117d-3a8c-5e74-8711-168153e19545","title":"Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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