{"id":"aa29ca00-e3ca-502e-8410-ae09c2fb27e4","stable_key":"e3f6ce02-0bd7-5103-acc1-68503ab6751b:fsl-salicylate","predicate":"decreases_in_recorded_comparison","statement":"Sodium salicylate prevented ALCAR-induced mGlu2 protein upregulation in FSL rats.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"5e7763bc-100d-53d7-984a-7a5b0000412f","mechanism_event_label":"Sodium salicylate prevented ALCAR-induced mGlu2 protein upregulation in FSL rats.","subject":{"id":"4911aeb4-39a4-5fb4-8c27-1599876a9520","slug":"sodium-salicylate","display_name":"Sodium salicylate","entity_type_key":"drug"},"object":{"id":"1dd1a4e1-dc80-5297-8b76-98652b5150ce","slug":"rat-grm2","display_name":"Rat metabotropic glutamate receptor 2 / Grm2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"5e7763bc-100d-53d7-984a-7a5b0000412f","stable_key":"e3f6ce02-0bd7-5103-acc1-68503ab6751b:fsl-salicylate-event","event_type":"experimental_observation","label":"Sodium salicylate prevented ALCAR-induced mGlu2 protein upregulation in FSL rats.","description":"### fsl-salicylate\n\nSodium salicylate prevented ALCAR-induced mGlu2 protein upregulation in FSL rats.\nThe inhibitor was nonselective. This does not establish an ordinary aspirin-food interaction or prove acetyl-group provenance.\nModel and exposure: Salicylate 50 mg/kg intraperitoneal with ALCAR 100 mg/kg intraperitoneal for 21 days; Fig. 3D.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. | 2013 | https://pubmed.ncbi.nlm.nih.gov/23382250/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC3607061/ | https://doi.org/10.1073/pnas.1216100110 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4911aeb4-39a4-5fb4-8c27-1599876a9520","slug":"sodium-salicylate","display_name":"Sodium salicylate","entity_type_key":"drug"},"role":"tested factor","stoichiometry":null,"state_label":"Salicylate plus ALCAR","sequence_order":0,"notes":""},{"entity":{"id":"1dd1a4e1-dc80-5297-8b76-98652b5150ce","slug":"rat-grm2","display_name":"Rat metabotropic glutamate receptor 2 / Grm2","entity_type_key":"protein"},"role":"measured outcome","stoichiometry":null,"state_label":"decrease","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_condition","value_text":"100 mg/kg","comparator":"ALCAR alone","unit":null,"notes":"Condition belongs to the full experimental contrast; do not separate a joint intervention.","entity":{"slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"}},{"dimension":"experimental_condition","value_text":"50 mg/kg","comparator":"ALCAR alone","unit":null,"notes":"Condition belongs to the full experimental contrast; do not separate a joint intervention.","entity":{"slug":"sodium-salicylate","display_name":"Sodium salicylate","entity_type_key":"drug"}},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Salicylate plus ALCAR\", \"comparator\": \"ALCAR alone\", \"endpoint\": \"Sodium salicylate prevented ALCAR-induced mGlu2 protein upregulation in FSL rats.\", \"effect_direction\": \"decrease\", \"combination\": \"joint\", \"conditions\": [{\"entity_slug\": \"sodium-salicylate\", \"state\": \"50 mg/kg\"}, {\"entity_slug\": \"acetylcarnitine\", \"state\": \"100 mg/kg\"}]}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Salicylate 50 mg/kg intraperitoneal with ALCAR 100 mg/kg intraperitoneal for 21 days; Fig. 3D.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived curation with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Acetyl-L-carnitine collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Sodium salicylate prevented ALCAR-induced mGlu2 protein upregulation in FSL rats.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. | https://pubmed.ncbi.nlm.nih.gov/23382250/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC3607061/ | https://doi.org/10.1073/pnas.1216100110","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference fsl-salicylate; The inhibitor was nonselective. This does not establish an ordinary aspirin-food interaction or prove acetyl-group provenance.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7860701e-4a1c-5ab5-8a01-9639498dc73b","evidence_kind":"source_excerpt","locator":"Lines 232-238","start_line":232,"end_line":238,"excerpt":"### fsl-salicylate\n\nSodium salicylate prevented ALCAR-induced mGlu2 protein upregulation in FSL rats.\nThe inhibitor was nonselective. This does not establish an ordinary aspirin-food interaction or prove acetyl-group provenance.\nModel and exposure: Salicylate 50 mg/kg intraperitoneal with ALCAR 100 mg/kg intraperitoneal for 21 days; Fig. 3D.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. | 2013 | https://pubmed.ncbi.nlm.nih.gov/23382250/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC3607061/ | https://doi.org/10.1073/pnas.1216100110 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","model_system":"Salicylate 50 mg/kg intraperitoneal with ALCAR 100 mg/kg intraperitoneal for 21 days; Fig. 3D.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2588f904-245a-597a-8a12-65118013fb90","stable_key":"import-e3f6ce02-0bd7-5103-acc1-68503ab6751b","title":"Acetyl-L-carnitine: detailed mechanisms of action (reviewed 6 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original review of primary studies and clearly identified official records. Exact primary access is stated; no independent replication is claimed.","file_path":"","sha256":"84cc82d6fbb0fd5d73c4ce779e9f88e7f0184ba2d29b18ad0f153815380f2975","revision_id":"dac7a950-dbe5-5c7a-9c70-2ea711d5c71a","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}