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(2015). https://pubmed.ncbi.nlm.nih.gov/25532619/ DOI: 10.1111/wrr.12253","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Dermal fibroblasts and diabetic wounds","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"c72acc97-4573-5a8d-9e2e-97fe4fb980bb","evidence_kind":"source_excerpt","locator":"Lines 634-645","start_line":634,"end_line":645,"excerpt":"### hbot-hif1-required-proliferation\nInduction of fibroblast proliferation by hyperbaric oxygen disappeared when HIF-1alpha was knocked down.\nCondition category: machinery_impairment\nnutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.\nplain_language: Take the sensor away and the cells stop responding to the treatment.\norganism: Human cells and mouse\ntissue_or_cell_type: Dermal fibroblasts and diabetic wounds\nexperimental_model: Human dermal fibroblasts, SKRC7 cells, HIF-1alpha knockout mouse embryonic fibroblasts, and db/db mice\nlimitations: The knockout arm carries the causal claim. The authors describe the stabilisation as non-canonical, so the route from oxygen to HIF stability here is not the classical hydroxylase route.\nexposure: Hyperbaric oxygen in vitro and in vivo, with adenoviral stable HIF-1alpha delivery\nevidence_span: {\"source_cache\": \"artifacts/hbot-research/25532619.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"bb139ca47291f581e4d45523657f9f244734ce42a3e44c5e460671e58946a3ac\", \"start_char\": 0, \"end_char\": 1943, \"text_sha256\": \"bb139ca47291f581e4d45523657f9f244734ce42a3e44c5e460671e58946a3ac\"}\n[hbot-p25532619] Hyperbaric oxygen therapy activates hypoxia-inducible factor 1 (HIF-1), which contributes to improved wound healing in diabetic mice. (2015). https://pubmed.ncbi.nlm.nih.gov/25532619/ DOI: 10.1111/wrr.12253","model_system":"Human dermal fibroblasts, SKRC7 cells, HIF-1alpha knockout mouse embryonic fibroblasts, and db/db mice","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [hbot-p25532619] Hyperbaric oxygen therapy activates hypoxia-inducible factor 1 (HIF-1), which contributes to improved wound healing in diabetic mice. 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