{"id":"a9ba1f98-9faf-5c90-b7aa-112cea80886d","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-pivalate-ketones","predicate":"impairs_in_subset","statement":"After pivmecillinam-associated carnitine depletion, two of six subjects showed impaired ketone production during a 36-hour fast.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"34999248-0d9b-5964-9736-1a949cb23ca1","mechanism_event_label":"Low carnitine can limit the switch to fat-derived fasting fuel.","subject":{"id":"c0d23d5c-90c3-5d02-8cac-9f7d2bc10d28","slug":"pivmecillinam","display_name":"Pivmecillinam","entity_type_key":"small_molecule"},"object":{"id":"9851509b-8026-52c2-9eac-c0f9d71f1b0b","slug":"human-pivalate-fasting-ketogenesis","display_name":"Human fasting ketone production after pivmecillinam","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"34999248-0d9b-5964-9736-1a949cb23ca1","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-pivalate-ketones-event","event_type":"observed_relationship","label":"Low carnitine can limit the switch to fat-derived fasting fuel.","description":"After pivmecillinam-associated carnitine depletion, two of six subjects showed impaired ketone production during a 36-hour fast.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c0d23d5c-90c3-5d02-8cac-9f7d2bc10d28","slug":"pivmecillinam","display_name":"Pivmecillinam","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9851509b-8026-52c2-9eac-c0f9d71f1b0b","slug":"human-pivalate-fasting-ketogenesis","display_name":"Human fasting ketone production after pivmecillinam","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"0415581d-4a60-53bd-baf4-17405b3bb41f","slug":"serum-l-carnitine","display_name":"Human serum L-carnitine concentration","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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