{"id":"a9ad6658-7c26-55b9-9182-40e61f00700c","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-podocyte-p27","predicate":"increases_expression","statement":"Fisetin restored Cdkn1b expression in high-glucose-exposed mouse podocytes and diabetic mouse kidney.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"1aa27a33-ccd1-5b00-84b1-d4191e08ac4c","mechanism_event_label":"A cell-cycle regulator was linked to protection.","subject":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"object":{"id":"bffebe7d-585f-5975-bab6-49c744409f5e","slug":"mouse-cdkn1b","display_name":"Mouse p27 / Cdkn1b","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"1aa27a33-ccd1-5b00-84b1-d4191e08ac4c","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-podocyte-p27-event","event_type":"observed_relationship","label":"A cell-cycle regulator was linked to protection.","description":"Fisetin restored Cdkn1b expression in high-glucose-exposed mouse podocytes and diabetic mouse kidney.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bffebe7d-585f-5975-bab6-49c744409f5e","slug":"mouse-cdkn1b","display_name":"Mouse p27 / Cdkn1b","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Immortalized mouse podocytes and streptozotocin diabetic mice.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Docking suggests a possible interaction but does not demonstrate direct binding.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A cell-cycle regulator was linked to protection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Fisetin Attenuates Diabetic Nephropathy-Induced Podocyte Injury by Inhibiting NLRP3 Inflammasome. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35126159/ · DOI 10.3389/fphar.2022.783706","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"182ae26f-220f-527f-8b31-5deb5ee3b7b2","evidence_kind":"source_excerpt","locator":"Lines 392-398","start_line":392,"end_line":398,"excerpt":"## fisetin-podocyte-p27\nA cell-cycle regulator was linked to protection.\nFisetin restored Cdkn1b expression in high-glucose-exposed mouse podocytes and diabetic mouse kidney.\nModel: Immortalized mouse podocytes and streptozotocin diabetic mice.\nLimitations: Docking suggests a possible interaction but does not demonstrate direct binding.\nEvidence access: Primary full text\nFisetin Attenuates Diabetic Nephropathy-Induced Podocyte Injury by Inhibiting NLRP3 Inflammasome. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35126159/ · DOI 10.3389/fphar.2022.783706","model_system":"Immortalized mouse podocytes and streptozotocin diabetic mice.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c30e0764cd34bd062cfcbfaf32357ef29dfda30e7d4153c545178140f5054e09","revision_id":"40ff52c0-f4b9-5820-8abb-ff002c6364a4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}