{"id":"a97ef12d-2004-57d3-a4b4-280d3b183176","stable_key":"f812c44f-d0fd-5f01-ba2c-748c0794fcfb:coumarin-rat-protein-clearance","predicate":"increases","statement":"Coumarin accelerated tissue protein removal relative to nonmetabolizable PVP in rat edema models; enhanced proteolysis was proposed.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4c5ebf9f-9fb8-5af0-b660-f4ac0a161129","mechanism_event_label":"Breaking down trapped proteins was proposed to help fluid leave tissue.","subject":{"id":"9fd9b93a-fdfd-5e09-92d3-0495bff41391","slug":"coumarin","display_name":"Coumarin","entity_type_key":"small_molecule"},"object":{"id":"28d52ff5-9c84-5f78-ad19-7ce6a6e27282","slug":"rat-edema-protein-clearance","display_name":"Rat edematous-tissue protein clearance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4c5ebf9f-9fb8-5af0-b660-f4ac0a161129","stable_key":"f812c44f-d0fd-5f01-ba2c-748c0794fcfb:coumarin-rat-protein-clearance-event","event_type":"biochemical_relationship","label":"Breaking down trapped proteins was proposed to help fluid leave tissue.","description":"Coumarin accelerated tissue protein removal relative to nonmetabolizable PVP in rat edema models; enhanced proteolysis was proposed.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9fd9b93a-fdfd-5e09-92d3-0495bff41391","slug":"coumarin","display_name":"Coumarin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"28d52ff5-9c84-5f78-ad19-7ce6a6e27282","slug":"rat-edema-protein-clearance","display_name":"Rat edematous-tissue protein clearance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coumarin-research/1212425.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6bb270c1b4bf1aecb2d3340d80c5721afe0bdfab2db86ce53384dce46fa75db1\", \"start_char\": 0, \"end_char\": 976, \"text_sha256\": \"6bb270c1b4bf1aecb2d3340d80c5721afe0bdfab2db86ce53384dce46fa75db1\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Protein clearance compared with nonmetabolizable PVP tracer","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Experimental coumarin treatment; dose not stated in indexed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Proteolysis is the authors proposed explanation; individual proteases were not identified in the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coumarin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coumarin","display_name":"Coumarin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Breaking down trapped proteins was proposed to help fluid leave tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coumarin-p1212425] The effect of coumarin on protein and PVP clearance from rat legs with various high protein oedemas. (1975). https://pubmed.ncbi.nlm.nih.gov/1212425/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Normal, burned and lymph-edematous leg tissues","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7989ed75-c59e-59f9-98dc-6650cfbcc170","evidence_kind":"source_excerpt","locator":"Lines 293-304","start_line":293,"end_line":304,"excerpt":"### coumarin-rat-protein-clearance\nCoumarin accelerated tissue protein removal relative to nonmetabolizable PVP in rat edema models; enhanced proteolysis was proposed.\nCondition category: normal\nnutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Breaking down trapped proteins was proposed to help fluid leave tissue.\norganism: Rat\ntissue_or_cell_type: Normal, burned and lymph-edematous leg tissues\nexperimental_model: Protein clearance compared with nonmetabolizable PVP tracer\nlimitations: Proteolysis is the authors proposed explanation; individual proteases were not identified in the abstract.\nexposure: Experimental coumarin treatment; dose not stated in indexed abstract\nevidence_span: {\"source_cache\": \"artifacts/coumarin-research/1212425.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6bb270c1b4bf1aecb2d3340d80c5721afe0bdfab2db86ce53384dce46fa75db1\", \"start_char\": 0, \"end_char\": 976, \"text_sha256\": \"6bb270c1b4bf1aecb2d3340d80c5721afe0bdfab2db86ce53384dce46fa75db1\"}\n[coumarin-p1212425] The effect of coumarin on protein and PVP clearance from rat legs with various high protein oedemas. (1975). https://pubmed.ncbi.nlm.nih.gov/1212425/","model_system":"Protein clearance compared with nonmetabolizable PVP tracer","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [coumarin-p1212425] The effect of coumarin on protein and PVP clearance from rat legs with various high protein oedemas. (1975). https://pubmed.ncbi.nlm.nih.gov/1212425/","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"30e0bbf1-757c-5baf-9102-e81bdd4382f0","stable_key":"import-f812c44f-d0fd-5f01-ba2c-748c0794fcfb","title":"Coumarin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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