{"id":"a915eabf-fe5f-558e-9669-4676594c8ddc","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:avian-reversal","predicate":"context_dependent_observation","statement":"Thymulin produced opposite IL-2-receptor-positive lymphocyte responses in normal versus hypothyroid chicken strains.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"621bedbd-cd00-5ec2-be32-cd1b25d26ee2","mechanism_event_label":"Thymulin produced opposite IL-2-receptor-positive lymphocyte responses in normal versus hypothyroid chicken strains.","subject":{"id":"23819462-9bdf-5856-beac-68b3dca9cf85","slug":"thymulin","display_name":"Thymulin","entity_type_key":"peptide"},"object":{"id":"4dfeafd1-19c5-5b75-9314-3518e6c6fd87","slug":"chicken-il2r-positive-lymphocytes","display_name":"Chicken IL-2-receptor-positive lymphocyte proportion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"621bedbd-cd00-5ec2-be32-cd1b25d26ee2","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:avian-reversal-event","event_type":"experimental_observation","label":"Thymulin produced opposite IL-2-receptor-positive lymphocyte responses in normal versus hypothyroid chicken strains.","description":"Context dependence extends to target-cell markers: an avian study reported opposite changes in the proportion of IL-2-receptor-positive lymphocytes in normal versus hypothyroid chicken strains. This cannot be transferred directly to human disease, but it prevents a universal “thymulin increases IL-2 receptors” rule. [Avian IL-2-receptor experiment](https://pubmed.ncbi.nlm.nih.gov/11090697/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"23819462-9bdf-5856-beac-68b3dca9cf85","slug":"thymulin","display_name":"Thymulin","entity_type_key":"peptide"},"role":"tested factor","stoichiometry":null,"state_label":"Thymulin in normal versus hypothyroid chickens","sequence_order":0,"notes":""},{"entity":{"id":"4dfeafd1-19c5-5b75-9314-3518e6c6fd87","slug":"chicken-il2r-positive-lymphocytes","display_name":"Chicken IL-2-receptor-positive lymphocyte proportion","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"mixed","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary bibliographic record and abstract checked; full methods/figures not comprehensively reviewed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Thymulin in normal versus hypothyroid chickens\", \"comparator\": \"Corresponding strain controls\", \"endpoint\": \"Thymulin produced opposite IL-2-receptor-positive lymphocyte responses in normal versus hypothyroid chicken strains.\", \"effect_direction\": \"mixed\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Avian lymphocytes; normal and hypothyroid strains, not human efficacy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Thymulin produced opposite IL-2-receptor-positive lymphocyte responses in normal versus hypothyroid chicken strains.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effect of thymulin on avian IL-2 receptor expression. | 2000 | DOI 10.1016/s0192-0561(00)00051-5 | PMID 11090697 | https://pubmed.ncbi.nlm.nih.gov/11090697/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 58-58; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c2a1ff80-5165-598e-86ae-d36d8ef40aff","evidence_kind":"source_excerpt","locator":"Lines 58-58","start_line":58,"end_line":58,"excerpt":"Context dependence extends to target-cell markers: an avian study reported opposite changes in the proportion of IL-2-receptor-positive lymphocytes in normal versus hypothyroid chicken strains. This cannot be transferred directly to human disease, but it prevents a universal “thymulin increases IL-2 receptors” rule. [Avian IL-2-receptor experiment](https://pubmed.ncbi.nlm.nih.gov/11090697/)","model_system":"Avian lymphocytes; normal and hypothyroid strains, not human efficacy.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e1871d49-9c6b-547b-a1bb-6e2b9270ca89","stable_key":"import-18100170-a014-51c3-adeb-9dab4162b8cc","title":"Thymulin: detailed mechanisms of action (reviewed 3 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. 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