{"id":"a9066819-4ee3-581c-9f84-e319b77725a1","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-renal-clearance","predicate":"has_concentration_dependent_clearance","statement":"Rapid early disappearance after intravenous dosing included concentration-dependent renal clearance; renal elimination was not observed after the 10 g oral dose.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5c3518b4-ef75-58de-b9ff-2c207f611b05","mechanism_event_label":"Route and concentration changed how arginine was removed.","subject":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"object":{"id":"7ca1341f-6d41-5821-b135-1f4e6d84a631","slug":"arginine-renal-clearance","display_name":"Renal clearance of arginine","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5c3518b4-ef75-58de-b9ff-2c207f611b05","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-renal-clearance-event","event_type":"observed_relationship","label":"Route and concentration changed how arginine was removed.","description":"Rapid early disappearance after intravenous dosing included concentration-dependent renal clearance; renal elimination was not observed after the 10 g oral dose.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7ca1341f-6d41-5821-b135-1f4e6d84a631","slug":"arginine-renal-clearance","display_name":"Renal clearance of arginine","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy-volunteer pharmacokinetic study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not extrapolate this pattern unchanged to kidney disease.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Route and concentration changed how arginine was removed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Pharmacokinetics of intravenous and oral L-arginine in normal volunteers. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10215749/ · DOI 10.1046/j.1365-2125.1999.00883.x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9bbdf894-3bd5-5908-88d4-f016b81a50f7","evidence_kind":"source_excerpt","locator":"Lines 358-364","start_line":358,"end_line":364,"excerpt":"## arg-renal-clearance\nRoute and concentration changed how arginine was removed.\nRapid early disappearance after intravenous dosing included concentration-dependent renal clearance; renal elimination was not observed after the 10 g oral dose.\nModel: Healthy-volunteer pharmacokinetic study.\nLimitations: Do not extrapolate this pattern unchanged to kidney disease.\nEvidence access: Primary abstract\nPharmacokinetics of intravenous and oral L-arginine in normal volunteers. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10215749/ · DOI 10.1046/j.1365-2125.1999.00883.x","model_system":"Healthy-volunteer pharmacokinetic study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"ec0e9a3fb72b7485534e4372a074ac7624a399ff962e55690eb462217b5149ec","revision_id":"af027270-5535-51ae-85ff-9c76c518c962","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}