{"id":"a903e4d9-2ddb-50a4-91d9-6970dbb56ebc","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-matrix-versus-mineral","predicate":"separates_matrix_from_mineral","statement":"Strontium strongly inhibited mineral deposition while collagenous matrix structures remained apparent and osteoblast numbers were unchanged; ionized calcium remained in the medium.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4a6e64a5-6291-5a7f-b0b7-f45acd524f91","mechanism_event_label":"Making a scaffold and depositing calcium mineral are different steps.","subject":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"object":{"id":"342f4527-e252-55ef-a855-737ca76584e1","slug":"rat-calvarial-strontium-mineralization","display_name":"Mineralization in strontium-treated rat calvarial osteoblast cultures","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4a6e64a5-6291-5a7f-b0b7-f45acd524f91","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-matrix-versus-mineral-event","event_type":"observed_relationship","label":"Making a scaffold and depositing calcium mineral are different steps.","description":"Strontium strongly inhibited mineral deposition while collagenous matrix structures remained apparent and osteoblast numbers were unchanged; 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molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Making a scaffold and depositing calcium mineral are different steps.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25048011/ · DOI 10.1007/s00198-014-2791-5","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7f751592-6b7d-556a-a21c-8c7bd005a55b","evidence_kind":"source_excerpt","locator":"Lines 278-284","start_line":278,"end_line":284,"excerpt":"## strontium-matrix-versus-mineral\nMaking a scaffold and depositing calcium mineral are different steps.\nStrontium strongly inhibited mineral deposition while collagenous matrix structures remained apparent and osteoblast numbers were unchanged; ionized calcium remained in the medium.\nModel: Same rat primary osteoblast cultures.\nLimitations: Does not establish that all bone effects are physicochemical, nor deny fracture outcomes in a clinical trial.\nEvidence access: Primary full text\nStrontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25048011/ · DOI 10.1007/s00198-014-2791-5","model_system":"Same rat primary osteoblast cultures.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"43ef0fe7-eb6c-5346-8381-f7694733b4dc","stable_key":"import-1ff3a29f-ef80-5bff-9300-30b98c60b90d","title":"Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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