{"id":"a8d6951f-0fb6-5947-b013-f7fbabf85d63","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:pipox-pipecolate-oxidation","predicate":"converted_to","statement":"Human peroxisomal PIPOX oxidizes L-pipecolate to P6C.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"544d89d4-6574-57f9-81e7-0281b102c88e","mechanism_event_label":"Pipecolate can join the common lysine breakdown route.","subject":{"id":"788366f7-4a9d-51e7-adbd-0a87afe092c0","slug":"pipecolate","display_name":"L-Pipecolate","entity_type_key":"small_molecule"},"object":{"id":"9a7b1d83-ebb2-5dea-b4a7-c040502fba4d","slug":"piperideine-6-carboxylate","display_name":"Delta1-piperideine-6-carboxylate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"544d89d4-6574-57f9-81e7-0281b102c88e","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:pipox-pipecolate-oxidation-event","event_type":"biochemical_relationship","label":"Pipecolate can join the common lysine breakdown route.","description":"Human peroxisomal PIPOX oxidizes L-pipecolate to P6C.","status":"provisional","compartment":{"slug":"peroxisome","display_name":"Peroxisome"},"participants":[{"entity":{"id":"d756caca-0a1f-524b-9731-a35a0aa88bfe","slug":"pipox","display_name":"L-Pipecolate oxidase / PIPOX","entity_type_key":"protein"},"role":"catalyst","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"788366f7-4a9d-51e7-adbd-0a87afe092c0","slug":"pipecolate","display_name":"L-Pipecolate","entity_type_key":"small_molecule"},"role":"substrate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9a7b1d83-ebb2-5dea-b4a7-c040502fba4d","slug":"piperideine-6-carboxylate","display_name":"Delta1-piperideine-6-carboxylate","entity_type_key":"small_molecule"},"role":"product","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Human cDNA cloning and expressed enzyme","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Enzyme capability does not establish that this route predominates in human brain; see conflict.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Pipecolate can join the common lysine breakdown route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ijlst2000] Molecular cloning and expression of human L-pipecolate oxidase (2000). https://pubmed.ncbi.nlm.nih.gov/10772957/ DOI: 10.1006/bbrc.2000.2575","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Peroxisomes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d90e0be5-4840-528b-836c-f39ef2430811","evidence_kind":"source_excerpt","locator":"Lines 146-154","start_line":146,"end_line":154,"excerpt":"### pipox-pipecolate-oxidation\nHuman peroxisomal PIPOX oxidizes L-pipecolate to P6C.\nPlain language: Pipecolate can join the common lysine breakdown route.\nCondition category: normal\norganism: Homo sapiens\ntissue_or_cell_type: Peroxisomes\nexperimental_model: Human cDNA cloning and expressed enzyme\nlimitations: Enzyme capability does not establish that this route predominates in human brain; see conflict.\n[ijlst2000] Molecular cloning and expression of human L-pipecolate oxidase (2000). https://pubmed.ncbi.nlm.nih.gov/10772957/ DOI: 10.1006/bbrc.2000.2575","model_system":"Human cDNA cloning and expressed enzyme","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact quote from the accompanying curation document, not from publisher text. Original study references: [ijlst2000] Molecular cloning and expression of human L-pipecolate oxidase (2000). https://pubmed.ncbi.nlm.nih.gov/10772957/ DOI: 10.1006/bbrc.2000.2575","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7633bde7-dcc9-5086-91c6-a45eb96857f3","stable_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","title":"L-Lysine: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"93998d47c21525409ba82f1c82ededf2893dff15fbe61c7deffc175b0e298e97","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}