{"id":"a8ba6bf7-ad63-5a7d-8687-c2438ff8169d","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:renal-low-k-romk-internalization","predicate":"restriction-increases","statement":"After 48 hours of dietary K deficiency, rat CCD ROMK shifted from apical membrane toward endosomal/lysosomal locations.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"123aaa91-e537-5e46-8abe-986e6224ecf5","mechanism_event_label":"The kidney removes potassium exit channels from the surface when potassium is scarce.","subject":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"object":{"id":"22c568e4-bb53-5d51-96b5-8ec2a46a5bf7","slug":"romk-endocytosis","display_name":"ROMK endocytosis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"123aaa91-e537-5e46-8abe-986e6224ecf5","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:renal-low-k-romk-internalization-event","event_type":"biochemical_relationship","label":"The kidney removes potassium exit channels from the surface when potassium is scarce.","description":"After 48 hours of dietary K deficiency, rat CCD ROMK shifted from apical membrane toward endosomal/lysosomal locations.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"role":"causal-subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"22c568e4-bb53-5d51-96b5-8ec2a46a5bf7","slug":"romk-endocytosis","display_name":"ROMK endocytosis","entity_type_key":"cellular_process"},"role":"measured-target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bdc516b4-647c-52b3-9b85-c925a0aec2ce","slug":"kcnj1","display_name":"Renal outer medullary potassium channel / KCNJ1","entity_type_key":"protein"},"role":"channel","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"06561e72-e54f-53bb-aed8-9e9dfc78604b","slug":"romk-apical-abundance","display_name":"Apical ROMK channel abundance","entity_type_key":"cellular_process"},"role":"surface-pool","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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