{"id":"a8ab617c-3bc6-5a1a-a8cc-58bff9eccd17","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-ring-cleavage-product","predicate":"yields_microbial_metabolite","statement":"The study identified 3,4,5-trihydroxyphenylacetic acid as a microbial-derived myricetin metabolite investigated for further amination.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"350ae0eb-3b8f-57da-98fa-c62932f06db3","mechanism_event_label":"Microbial breakdown produces a smaller chemical scaffold.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"a623595e-fdd7-5be0-8009-dab4b3acf418","slug":"3-4-5-trihydroxyphenylacetic-acid","display_name":"3,4,5-Trihydroxyphenylacetic acid","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"350ae0eb-3b8f-57da-98fa-c62932f06db3","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-ring-cleavage-product-event","event_type":"observed_relationship","label":"Microbial breakdown produces a smaller chemical scaffold.","description":"The study identified 3,4,5-trihydroxyphenylacetic acid as a microbial-derived myricetin metabolite investigated for further amination.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a623595e-fdd7-5be0-8009-dab4b3acf418","slug":"3-4-5-trihydroxyphenylacetic-acid","display_name":"3,4,5-Trihydroxyphenylacetic acid","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse biotransformation study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No specific strain, enzyme or human conversion fraction established by this record.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Microbial breakdown produces a smaller chemical scaffold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Biotransformation of Myricetin: A Novel Metabolic Pathway to Produce Aminated Products in Mice. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31087612/ · DOI 10.1002/mnfr.201900203","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"23886563-9629-5815-a395-7e938b03f31e","evidence_kind":"source_excerpt","locator":"Lines 68-74","start_line":68,"end_line":74,"excerpt":"## myricetin-ring-cleavage-product\nMicrobial breakdown produces a smaller chemical scaffold.\nThe study identified 3,4,5-trihydroxyphenylacetic acid as a microbial-derived myricetin metabolite investigated for further amination.\nModel: Mouse biotransformation study.\nLimitations: No specific strain, enzyme or human conversion fraction established by this record.\nEvidence access: Primary abstract\nBiotransformation of Myricetin: A Novel Metabolic Pathway to Produce Aminated Products in Mice. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31087612/ · DOI 10.1002/mnfr.201900203","model_system":"Mouse biotransformation study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0abf512275cf3aae9e4ec8544f1cde97e0155d0cfb5be12a193cdd5a898386a7","revision_id":"422e342f-a55c-5e73-ba98-43df560f49b9","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}