{"id":"a88e00f2-0391-5238-996b-6684fedd4c7b","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:calcitriol-suppresses-pth-transcription","predicate":"inhibits","statement":"Calcitriol administration suppresses parathyroid PTH transcription in rats without a measured rise in serum calcium.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"4ccec3fe-a0dd-5598-9c51-f792091ae9b6","mechanism_event_label":"Active vitamin D feeds back on hormone production.","subject":{"id":"f5156c24-108f-5746-b114-ed764e79a3f4","slug":"calcitriol","display_name":"Calcitriol","entity_type_key":"small_molecule"},"object":{"id":"ec064895-ba0b-5e9f-9255-1e71fca9f3fc","slug":"pth-transcription","display_name":"Parathyroid hormone gene transcription","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4ccec3fe-a0dd-5598-9c51-f792091ae9b6","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:calcitriol-suppresses-pth-transcription-event","event_type":"biochemical_relationship","label":"Active vitamin D feeds back on hormone production.","description":"Calcitriol administration suppresses parathyroid PTH transcription in rats without a measured rise in serum calcium.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f5156c24-108f-5746-b114-ed764e79a3f4","slug":"calcitriol","display_name":"Calcitriol","entity_type_key":"small_molecule"},"role":"regulator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e162b0ab-1449-5471-b3c3-4638a0fa3a96","slug":"pth","display_name":"Parathyroid hormone / PTH","entity_type_key":"protein"},"role":"gene_product","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ec064895-ba0b-5e9f-9255-1e71fca9f3fc","slug":"pth-transcription","display_name":"Parathyroid hormone gene transcription","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Vitamin D metabolite administration to rats; parathyroid RNA and nuclear transcription assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Administered hormone and transcription assay; does not resolve every promoter mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Active vitamin D feeds back on hormone production.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[silver1986] Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat (1986). https://pubmed.ncbi.nlm.nih.gov/3771798/ DOI: 10.1172/JCI112714","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Parathyroid","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"87588156-7272-55a8-842c-68fe64a6d1d3","evidence_kind":"source_excerpt","locator":"Lines 80-89","start_line":80,"end_line":89,"excerpt":"### calcitriol-suppresses-pth-transcription\nCalcitriol administration suppresses parathyroid PTH transcription in rats without a measured rise in serum calcium.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Active vitamin D feeds back on hormone production.\norganism: Rattus norvegicus\ntissue_or_cell_type: Parathyroid\nexperimental_model: Vitamin D metabolite administration to rats; parathyroid RNA and nuclear transcription assays\nlimitations: Administered hormone and transcription assay; does not resolve every promoter mechanism.\n[silver1986] Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat (1986). https://pubmed.ncbi.nlm.nih.gov/3771798/ DOI: 10.1172/JCI112714","model_system":"Vitamin D metabolite administration to rats; parathyroid RNA and nuclear transcription assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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