{"id":"a86d344f-adb1-533b-90b9-5f5241dc3555","stable_key":"8600a864-6653-52c7-9718-1362c5af4577:gamma-nonalactone-yeast-precursor","predicate":"is_biotransformed_to","statement":"Labeled-precursor experiments demonstrated conversion of 4-oxononanoic acid into gamma-nonalactone during yeast fermentation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"26f971b6-75e4-528c-9fa3-901ddea7bbf0","mechanism_event_label":"Labeled-precursor experiments demonstrated conversion of 4-oxononanoic acid into gamma-nonalactone during yeast fermentation.","subject":{"id":"54e49e1e-8efe-50bf-83b0-aa38ceb9493a","slug":"4-oxononanoic-acid","display_name":"4-Oxononanoic acid","entity_type_key":"small_molecule"},"object":{"id":"2b85fa4a-5c91-5de9-aead-a443bc4394af","slug":"gamma-nonalactone","display_name":"Gamma-nonalactone","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"26f971b6-75e4-528c-9fa3-901ddea7bbf0","stable_key":"8600a864-6653-52c7-9718-1362c5af4577:gamma-nonalactone-yeast-precursor-event","event_type":"observed_relationship","label":"Labeled-precursor experiments demonstrated conversion of 4-oxononanoic acid into gamma-nonalactone during yeast fermentation.","description":"Labeled-precursor experiments demonstrated conversion of 4-oxononanoic acid into gamma-nonalactone during yeast fermentation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"54e49e1e-8efe-50bf-83b0-aa38ceb9493a","slug":"4-oxononanoic-acid","display_name":"4-Oxononanoic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2b85fa4a-5c91-5de9-aead-a443bc4394af","slug":"gamma-nonalactone","display_name":"Gamma-nonalactone","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Labeled d6-4-oxononanoic acid; experimental spike concentration not given in abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Fermentation interval not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract; unresolved method details explicitly retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Saccharomyces cerevisiae alcoholic fermentation and grape/wine analyses","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Tracer evidence establishes precursor conversion in yeast; it does not establish a human pathway or identify individual reductase enzymes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gamma-nonalactone flavor-compound chapter; nutrient and drug interactions retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gamma-nonalactone","display_name":"Gamma-nonalactone","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Saccharomyces cerevisiae alcoholic fermentation and grape/wine analyses","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Labeled-precursor experiments demonstrated conversion of 4-oxononanoic acid into gamma-nonalactone during yeast fermentation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Aromatic Potential of Bordeaux Grape Cultivars: Identification and Assays on 4-Oxononanoic Acid, a γ-Nonalactone Precursor. (2020). https://pubmed.ncbi.nlm.nih.gov/32955257/ DOI: 10.1021/acs.jafc.0c04171","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Microbial precursor biotransformation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Fermenting must","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"95367dc0-1c03-5796-8eb1-553006f0e934","evidence_kind":"source_excerpt","locator":"Lines 158-167","start_line":158,"end_line":167,"excerpt":"## gamma-nonalactone-yeast-precursor\nLabeled-precursor experiments demonstrated conversion of 4-oxononanoic acid into gamma-nonalactone during yeast fermentation.\nModel/species: Saccharomyces cerevisiae alcoholic fermentation and grape/wine analyses\nTissue: Fermenting must\nExposure: Labeled d6-4-oxononanoic acid; experimental spike concentration not given in abstract\nRoute: Microbial precursor biotransformation\nDuration: Fermentation interval not specified in accessed abstract\nLimits: Tracer evidence establishes precursor conversion in yeast; it does not establish a human pathway or identify individual reductase enzymes.\nPrimary reference: Aromatic Potential of Bordeaux Grape Cultivars: Identification and Assays on 4-Oxononanoic Acid, a γ-Nonalactone Precursor. (2020). https://pubmed.ncbi.nlm.nih.gov/32955257/ DOI: 10.1021/acs.jafc.0c04171\nAccess: Primary PubMed abstract; unresolved method details explicitly retained.","model_system":"Saccharomyces cerevisiae alcoholic fermentation and grape/wine analyses","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73777c54-95a4-5b07-9d14-d4dd31949fb1","stable_key":"import-8600a864-6653-52c7-9718-1362c5af4577","title":"Gamma-nonalactone: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of eight primary studies. Study-specific citations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"a6fede6fbb2b70669be6846626f9c197edfd605c627d50fffa984e2b0b7ed71d","revision_id":"bb5ac9d2-d97d-59ac-a99c-ddf46d535574","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}