{"id":"a7b20546-82f8-5ddd-a432-db9b95457b62","stable_key":"e0801c92-7fd3-5cb2-82b7-dd82f010f3ed:ivermectin-lowers-glucose-through-fxr","predicate":"lowers_in_mice","statement":"Ivermectin decreased serum glucose and cholesterol in wild-type mice but not in FXR-null mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"f95ec3df-47b5-5a96-854e-5efdd02a9c3b","mechanism_event_label":"Ivermectin decreased serum glucose and cholesterol in wild-type mice but not in FXR-null mice.","subject":{"id":"416b9886-c6a5-5526-a8bf-b571a8d418bf","slug":"ivermectin","display_name":"Ivermectin","entity_type_key":"drug"},"object":{"id":"e4efb34e-ff1b-5f72-aacc-601c0e6ebafa","slug":"serum-glucose-concentration","display_name":"Serum glucose concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f95ec3df-47b5-5a96-854e-5efdd02a9c3b","stable_key":"e0801c92-7fd3-5cb2-82b7-dd82f010f3ed:ivermectin-lowers-glucose-through-fxr-event","event_type":"observed_relationship","label":"Ivermectin decreased serum glucose and cholesterol in wild-type mice but not in FXR-null mice.","description":"Ivermectin decreased serum glucose and cholesterol in wild-type mice but not in FXR-null mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"416b9886-c6a5-5526-a8bf-b571a8d418bf","slug":"ivermectin","display_name":"Ivermectin","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e4efb34e-ff1b-5f72-aacc-601c0e6ebafa","slug":"serum-glucose-concentration","display_name":"Serum glucose concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fcb53473-c0bd-5e70-891f-ab3b48353d25","slug":"nr1h4","display_name":"Human farnesoid X receptor / NR1H4","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Wild-type and FXR-null mice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Ivermectin treatment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The null-mouse comparison attributes the metabolic effect to FXR; it does not establish a dose relevant to human antiparasitic use.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Wild-type and FXR-null mice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Ivermectin decreased serum glucose and cholesterol in wild-type mice but not in FXR-null mice.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism. 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(2013). https://pubmed.ncbi.nlm.nih.gov/23728580/ DOI: 10.1038/ncomms2924\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"20818ddd-7b37-5226-a24b-7de007e80eb2","stable_key":"import-e0801c92-7fd3-5cb2-82b7-dd82f010f3ed","title":"Ivermectin: mechanism of action across parasite, host barrier and mammalian targets (2026-09-22)","document_type":"imported_text","citation_label":"Original AI-assisted curation of sixteen primary studies resolved by PubMed title search and cross-checked against live PubMed metadata. Study-specific citations, concentrations, negative findings and limitations retained. 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