{"id":"a7b18a90-f293-563a-850a-8e6d68377789","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-refeeding-low-mg-association","predicate":"low_baseline_is_associated_with","statement":"Low baseline serum magnesium was associated with subsequent refeeding syndrome in the cohort.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cc8cd2ab-ee53-5df7-8c88-d3110ba168c8","mechanism_event_label":"A mineral shortage was a risk signal alongside poor prior intake.","subject":{"id":"623a99ab-787c-5d78-8072-72cfcd82008e","slug":"serum-magnesium-concentration","display_name":"Serum magnesium concentration","entity_type_key":"cellular_process"},"object":{"id":"d4fcdbc8-631c-5bfc-b2d8-238541b23291","slug":"refeeding-electrolyte-fluid-disorder","display_name":"Electrolyte and fluid disorder during refeeding","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cc8cd2ab-ee53-5df7-8c88-d3110ba168c8","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-refeeding-low-mg-association-event","event_type":"observed_intervention","label":"A mineral shortage was a risk signal alongside poor prior intake.","description":"Low baseline serum magnesium was associated with subsequent refeeding syndrome in the cohort.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"measured_ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"nutrition_context","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"623a99ab-787c-5d78-8072-72cfcd82008e","slug":"serum-magnesium-concentration","display_name":"Serum magnesium concentration","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"d4fcdbc8-631c-5bfc-b2d8-238541b23291","slug":"refeeding-electrolyte-fluid-disorder","display_name":"Electrolyte and fluid disorder during refeeding","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Three syndrome events among 243 adults.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Study-specific exposure described in the model; no regimen inferred beyond the accessed evidence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Too few events for robust multivariable regression; association does not identify a universal causal bottleneck.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A mineral shortage was a risk signal alongside poor prior intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b1-rio2013] Occurrence of refeeding syndrome in adults started on artificial nutrition support: prospective cohort study (2013). https://pubmed.ncbi.nlm.nih.gov/23315514/ DOI: 10.1136/bmjopen-2012-002173","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum and clinical course","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"be913ff9-2f25-54bd-afb9-d679cdb5a0e1","evidence_kind":"source_excerpt","locator":"Lines 1746-1756","start_line":1746,"end_line":1756,"excerpt":"### b1-refeeding-low-mg-association\nLow baseline serum magnesium was associated with subsequent refeeding syndrome in the cohort.\nCondition category: biomarker_context\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A mineral shortage was a risk signal alongside poor prior intake.\norganism: Homo sapiens\ntissue_or_cell_type: Serum and clinical course\nexperimental_model: Three syndrome events among 243 adults.\nlimitations: Too few events for robust multivariable regression; association does not identify a universal causal bottleneck.\nexposure: Study-specific exposure described in the model; no regimen inferred beyond the accessed evidence.\n[b1-rio2013] Occurrence of refeeding syndrome in adults started on artificial nutrition support: prospective cohort study (2013). https://pubmed.ncbi.nlm.nih.gov/23315514/ DOI: 10.1136/bmjopen-2012-002173","model_system":"Three syndrome events among 243 adults.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b1-rio2013] Occurrence of refeeding syndrome in adults started on artificial nutrition support: prospective cohort study (2013). https://pubmed.ncbi.nlm.nih.gov/23315514/ DOI: 10.1136/bmjopen-2012-002173","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}