{"id":"a762f2c6-34e6-5194-9caf-d0114509bb43","stable_key":"63ce713e-6aea-59f6-9896-ca30e010b2ce:l-tyrosine-bacterial-drug","predicate":"consumes","statement":"Bacterial tyrosine decarboxylases converted levodopa to dopamine despite competing tyrosine or human decarboxylase inhibitors.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a439075a-b6f0-54f1-9b51-22e705a0bb52","mechanism_event_label":"Blocking the human enzyme may leave a microbial route active.","subject":{"id":"e8f2d674-296d-5160-9e98-c423f754ff59","slug":"enterococcus-faecalis-tyrosine-decarboxylase","display_name":"Enterococcus faecalis tyrosine decarboxylase","entity_type_key":"protein"},"object":{"id":"d2e54a66-7f3c-5bcc-adbe-9f66ad4264f4","slug":"l-dopa","display_name":"L-3,4-Dihydroxyphenylalanine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"a439075a-b6f0-54f1-9b51-22e705a0bb52","stable_key":"63ce713e-6aea-59f6-9896-ca30e010b2ce:l-tyrosine-bacterial-drug-event","event_type":"observed_relationship","label":"Blocking the human enzyme may leave a microbial route active.","description":"Bacterial tyrosine decarboxylases converted levodopa to dopamine despite competing tyrosine or human decarboxylase inhibitors.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e8f2d674-296d-5160-9e98-c423f754ff59","slug":"enterococcus-faecalis-tyrosine-decarboxylase","display_name":"Enterococcus faecalis tyrosine decarboxylase","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d2e54a66-7f3c-5bcc-adbe-9f66ad4264f4","slug":"l-dopa","display_name":"L-3,4-Dihydroxyphenylalanine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bcfef85f-831d-5439-ba51-1aef4b090441","slug":"l-tyrosine","display_name":"L-Tyrosine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9cca6209-0603-5ab7-96ad-2f3ae4b772d2","slug":"dopamine","display_name":"Dopamine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"db95e69b-dd32-5fd7-8615-62899f42c17e","slug":"tyramine","display_name":"Tyramine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Bacterial enzyme experiments, human PD associations and proximal-intestinal rat studies.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Patient abundance associations and rat plasma effects are not proof that changing dietary tyrosine improves levodopa response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Tyrosine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-tyrosine","display_name":"L-Tyrosine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Blocking the human enzyme may leave a microbial route active.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson's disease. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30659181/ · DOI 10.1038/s41467-019-08294-y","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5bba8dc8-ffad-57f2-868e-4f815ed0eae3","evidence_kind":"source_excerpt","locator":"Lines 340-346","start_line":340,"end_line":346,"excerpt":"## l-tyrosine-bacterial-drug\nBlocking the human enzyme may leave a microbial route active.\nBacterial tyrosine decarboxylases converted levodopa to dopamine despite competing tyrosine or human decarboxylase inhibitors.\nModel: Bacterial enzyme experiments, human PD associations and proximal-intestinal rat studies.\nLimitations: Patient abundance associations and rat plasma effects are not proof that changing dietary tyrosine improves levodopa response.\nEvidence access: Primary abstract\nGut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson's disease. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30659181/ · DOI 10.1038/s41467-019-08294-y","model_system":"Bacterial enzyme experiments, human PD associations and proximal-intestinal rat studies.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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