{"id":"a7597dac-6820-5006-bc5f-ba452ba6a488","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zinc-trans-placenta-znt1-restriction","predicate":"restricted_intake_reduces","statement":"Placental ZnT1 expression was lower in pregnant mice fed 15 mg zinc/kg diet than in those fed 50 mg/kg; the mRNA pattern was reflected at the protein level.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"7799d325-784d-5f3e-9fb4-8fe2705f8862","mechanism_event_label":"Moderately restricting maternal dietary zinc lowered placental ZnT1 in mice.","subject":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"object":{"id":"0e622737-7e0e-5bd0-a1a5-6dc117c5fe90","slug":"placental-znt1-abundance","display_name":"Placental ZnT1 abundance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7799d325-784d-5f3e-9fb4-8fe2705f8862","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zinc-trans-placenta-znt1-restriction-event","event_type":"observed_intervention","label":"Moderately restricting maternal dietary zinc lowered placental ZnT1 in mice.","description":"Placental ZnT1 expression was lower in pregnant mice fed 15 mg zinc/kg diet than in those fed 50 mg/kg; the mRNA pattern was reflected at the protein level.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c4368ba9-5b26-5862-b5f9-1a2d8b698d59","slug":"mouse-slc30a1","display_name":"Mouse ZnT1 (Slc30a1)","entity_type_key":"protein"},"role":"regulated_transporter","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0e622737-7e0e-5bd0-a1a5-6dc117c5fe90","slug":"placental-znt1-abundance","display_name":"Placental ZnT1 abundance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled pregnancy diets and placental RNA/protein assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"15 versus 50 mg zinc/kg diet from pregnancy onset to day 17; 150 mg/kg group also had lower expression than 50 mg/kg.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Nonmonotonic expression must not be converted into a monotonic transport-flux model. These mouse diets are not human dose instructions or serum thresholds.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Moderately restricting maternal dietary zinc lowered placental ZnT1 in mice.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zinc-trans-16914197] Zinc transporters in the mouse placenta show a coordinated regulatory response to changes in dietary zinc intake. (2007). https://pubmed.ncbi.nlm.nih.gov/16914197/ DOI: 10.1016/j.placenta.2006.07.002","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Placenta","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"f724f1dc-4658-5ce1-93b5-0a79621bafa9","evidence_kind":"source_excerpt","locator":"Lines 544-555","start_line":544,"end_line":555,"excerpt":"### zinc-trans-placenta-znt1-restriction\nPlacental ZnT1 expression was lower in pregnant mice fed 15 mg zinc/kg diet than in those fed 50 mg/kg; the mRNA pattern was reflected at the protein level.\nCondition category: nutrient_deficiency\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Moderately restricting maternal dietary zinc lowered placental ZnT1 in mice.\norganism: Mus musculus\ntissue_or_cell_type: Placenta\nexperimental_model: Controlled pregnancy diets and placental RNA/protein assays\nlimitations: Nonmonotonic expression must not be converted into a monotonic transport-flux model. These mouse diets are not human dose instructions or serum thresholds.\nexposure: 15 versus 50 mg zinc/kg diet from pregnancy onset to day 17; 150 mg/kg group also had lower expression than 50 mg/kg.\ncross_nutrient: false\n[zinc-trans-16914197] Zinc transporters in the mouse placenta show a coordinated regulatory response to changes in dietary zinc intake. (2007). https://pubmed.ncbi.nlm.nih.gov/16914197/ DOI: 10.1016/j.placenta.2006.07.002","model_system":"Controlled pregnancy diets and placental RNA/protein assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zinc-trans-16914197] Zinc transporters in the mouse placenta show a coordinated regulatory response to changes in dietary zinc intake. (2007). https://pubmed.ncbi.nlm.nih.gov/16914197/ DOI: 10.1016/j.placenta.2006.07.002","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"2e731dd54477ec1254e97df3323e1208d38f1375effed19252e71ab4f600d13a","revision_id":"c72258b9-ac09-5408-9d44-a921ad1f96a3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}