{"id":"a73646c7-12b9-5d88-b5c1-b5779a319de3","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-air-competition","predicate":"inhibits","statement":"Basolateral iodide reversibly inhibited thiocyanate transport, apparent Ki 9 ± 8 micromolar.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"fb9ab9d9-3339-5ee6-909f-139db52c30b9","mechanism_event_label":"Iodide can compete with another antimicrobial substrate during delivery.","subject":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"object":{"id":"a1fbf329-dc04-5bed-b184-6c339c4cf72a","slug":"airway-thiocyanate-transport","display_name":"Transepithelial airway thiocyanate transport","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fb9ab9d9-3339-5ee6-909f-139db52c30b9","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-air-competition-event","event_type":"observed_relationship","label":"Iodide can compete with another antimicrobial substrate during delivery.","description":"Basolateral iodide reversibly inhibited thiocyanate transport, apparent Ki 9 ± 8 micromolar.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a1fbf329-dc04-5bed-b184-6c339c4cf72a","slug":"airway-thiocyanate-transport","display_name":"Transepithelial airway thiocyanate transport","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5d54e0a3-869f-5132-82c9-4c0ff47cd400","slug":"thiocyanate-ion","display_name":"Thiocyanate ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"0d051c22-c0d2-5c22-91ad-4ee6894dc7a0","slug":"slc5a5","display_name":"Human sodium/iodide symporter / SLC5A5","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Human airway epithelial cells at an air–liquid interface; transepithelial radiotracer transport.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The proposed apical CFTR route was inferred pharmacologically, not proven by this experiment. This is iodide biology, not a KI-specific counter-ion effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Iodide can compete with another antimicrobial substrate during delivery.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Transcellular thiocyanate transport by human airway epithelia. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15345749/ · DOI 10.1113/jphysiol.2004.071548","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b2615c2d-47dd-5f70-8b58-0ffcd3112664","evidence_kind":"source_excerpt","locator":"Lines 144-150","start_line":144,"end_line":150,"excerpt":"## ki-air-competition\nIodide can compete with another antimicrobial substrate during delivery.\nBasolateral iodide reversibly inhibited thiocyanate transport, apparent Ki 9 ± 8 micromolar.\nModel: Human airway epithelial cells at an air–liquid interface; transepithelial radiotracer transport.\nLimitations: The proposed apical CFTR route was inferred pharmacologically, not proven by this experiment. This is iodide biology, not a KI-specific counter-ion effect.\nEvidence location: Primary abstract\nTranscellular thiocyanate transport by human airway epithelia. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15345749/ · DOI 10.1113/jphysiol.2004.071548","model_system":"Human airway epithelial cells at an air–liquid interface; transepithelial radiotracer transport.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. Not publisher full text.","file_path":"","sha256":"3ff9da818dd7a763a59c6abcff2eaee136d7f887a777034feaa5ba304a8fa6ce","revision_id":"53f2ae88-8a91-5326-ac49-3bb510ca78c3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}