{"id":"a6f14f20-7865-516d-86d1-b6a6afe8e94f","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-sheep-gh","predicate":"increases_tested","statement":"Intravenous D-aspartate at 0.05 or 0.1 mmol/kg/min for 20 minutes increased circulating growth hormone in wethers.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"079d130f-c54b-5d68-bfdb-af10b1278d6d","mechanism_event_label":"An intravenous animal experiment found an endocrine effect beyond testosterone.","subject":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"object":{"id":"61bd9c5c-63de-5222-a2b1-1a8aef4e5cda","slug":"sheep-plasma-growth-hormone","display_name":"Plasma growth hormone in wethers","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"079d130f-c54b-5d68-bfdb-af10b1278d6d","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-sheep-gh-event","event_type":"observed_relationship","label":"An intravenous animal experiment found an endocrine effect beyond testosterone.","description":"Intravenous D-aspartate at 0.05 or 0.1 mmol/kg/min for 20 minutes increased circulating growth hormone in wethers.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"61bd9c5c-63de-5222-a2b1-1a8aef4e5cda","slug":"sheep-plasma-growth-hormone","display_name":"Plasma growth hormone in wethers","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Castrated male sheep; high- and low-dose infusion tests.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not an oral human result. Pituitary tissue experiments did not show a statistically significant direct secretion effect, so the route remains unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An intravenous animal experiment found an endocrine effect beyond testosterone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"D-aspartate stimulates growth hormone secretion in wethers. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39432441/ · DOI 10.1093/jas/skae318","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"21652585-0082-5fed-93bc-888609542607","evidence_kind":"source_excerpt","locator":"Lines 416-422","start_line":416,"end_line":422,"excerpt":"## d-aspartate-sheep-gh\nAn intravenous animal experiment found an endocrine effect beyond testosterone.\nIntravenous D-aspartate at 0.05 or 0.1 mmol/kg/min for 20 minutes increased circulating growth hormone in wethers.\nModel: Castrated male sheep; high- and low-dose infusion tests.\nLimitations: Not an oral human result. Pituitary tissue experiments did not show a statistically significant direct secretion effect, so the route remains unresolved.\nEvidence access: Primary abstract\nD-aspartate stimulates growth hormone secretion in wethers. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39432441/ · DOI 10.1093/jas/skae318","model_system":"Castrated male sheep; high- and low-dose infusion tests.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3751103e-e256-5615-b24f-39cc76ccfb47","stable_key":"import-9a47f338-d127-5e4d-abf6-e99056833a69","title":"D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0a86a1008edb8a69dcc79409e76e3fd5ce59b0747be8cae8f21e43f871e76248","revision_id":"a1de4b66-263d-5452-8ed8-df853afba030","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}