{"id":"a6edeb95-16f8-549c-90fb-fd55f1a159ba","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-beta-catenin","predicate":"stabilizes","statement":"Adding t10,c12 CLA inhibited beta-catenin degradation and increased its interaction with PPAR-gamma.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"700c45a1-ad8f-582f-85f7-9a571c1b3a6a","mechanism_event_label":"A stabilized protein associated with the fat-cell regulator.","subject":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"object":{"id":"4e067665-ef26-5ff1-a14b-d91623f10507","slug":"mouse-ctnnb1","display_name":"Mouse beta-catenin / Ctnnb1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"700c45a1-ad8f-582f-85f7-9a571c1b3a6a","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-beta-catenin-event","event_type":"observed_relationship","label":"A stabilized protein associated with the fat-cell regulator.","description":"Adding t10,c12 CLA inhibited beta-catenin degradation and increased its interaction with PPAR-gamma.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4e067665-ef26-5ff1-a14b-d91623f10507","slug":"mouse-ctnnb1","display_name":"Mouse beta-catenin / Ctnnb1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e9622fd-f3a4-526b-9ab5-7389d768d937","slug":"mouse-pparg","display_name":"Mouse peroxisome proliferator-activated receptor gamma / Pparg","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9c2c183b-516b-57db-b4e2-79848ddef558","slug":"mouse-pparg-ctnnb1-complex","display_name":"Mouse Pparg–beta-catenin complex","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse 3T3-L1 adipocytes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No universal activation of every Wnt target was observed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A stabilized protein associated with the fat-cell regulator.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Trans10, cis12 conjugated linoleic acid inhibits 3T3-L1 adipocyte adipogenesis by elevating β-catenin levels. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26780430/ · DOI 10.1016/j.bbalip.2016.01.004","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c1d106a9-7f04-531a-9a4b-4aac59e045ec","evidence_kind":"source_excerpt","locator":"Lines 206-212","start_line":206,"end_line":212,"excerpt":"## cla-beta-catenin\nA stabilized protein associated with the fat-cell regulator.\nAdding t10,c12 CLA inhibited beta-catenin degradation and increased its interaction with PPAR-gamma.\nModel: Mouse 3T3-L1 adipocytes.\nLimitations: No universal activation of every Wnt target was observed.\nEvidence access: Primary abstract\nTrans10, cis12 conjugated linoleic acid inhibits 3T3-L1 adipocyte adipogenesis by elevating β-catenin levels. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26780430/ · DOI 10.1016/j.bbalip.2016.01.004","model_system":"Mouse 3T3-L1 adipocytes.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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