{"id":"a6d889fc-027d-5196-9679-23b8671aa660","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-restriction-therapy-metabolism","predicate":"sensitizes_tested","statement":"Restriction altered one-carbon, nucleotide and redox metabolism and improved treatment responses in colorectal xenograft and autochthonous sarcoma models.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ff247223-ecc3-5a08-9bbd-bbe104a82bac","mechanism_event_label":"Diet composition modified pathways also targeted by cancer treatment.","subject":{"id":"2fa490e6-50cc-5a22-b1ea-af5e128666e4","slug":"experimental-methionine-restriction","display_name":"Experimentally methionine-restricted diet","entity_type_key":"cellular_process"},"object":{"id":"00e3576f-d700-5b50-ac4b-677eb53306df","slug":"mouse-mr-cancer-treatment-response","display_name":"Cancer treatment response in the methionine-restriction mouse study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ff247223-ecc3-5a08-9bbd-bbe104a82bac","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-restriction-therapy-metabolism-event","event_type":"observed_relationship","label":"Diet composition modified pathways also targeted by cancer treatment.","description":"Restriction altered one-carbon, nucleotide and redox metabolism and improved treatment responses in colorectal xenograft and autochthonous sarcoma models.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2fa490e6-50cc-5a22-b1ea-af5e128666e4","slug":"experimental-methionine-restriction","display_name":"Experimentally methionine-restricted diet","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"00e3576f-d700-5b50-ac4b-677eb53306df","slug":"mouse-mr-cancer-treatment-response","display_name":"Cancer treatment response in the methionine-restriction mouse study","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Patient-derived colorectal xenografts and Kras/Trp53-driven mouse sarcoma; antimetabolite/radiation settings.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different models and immune contexts from other tumor studies; not a human cancer efficacy trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Methionine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Diet composition modified pathways also targeted by cancer treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Dietary methionine influences therapy in mouse cancer models and alters human metabolism. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31367041/ · DOI 10.1038/s41586-019-1437-3","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9e90dcc9-baec-59b7-bc22-efbd21318b73","evidence_kind":"source_excerpt","locator":"Lines 484-490","start_line":484,"end_line":490,"excerpt":"## methionine-restriction-therapy-metabolism\nDiet composition modified pathways also targeted by cancer treatment.\nRestriction altered one-carbon, nucleotide and redox metabolism and improved treatment responses in colorectal xenograft and autochthonous sarcoma models.\nModel: Patient-derived colorectal xenografts and Kras/Trp53-driven mouse sarcoma; antimetabolite/radiation settings.\nLimitations: Different models and immune contexts from other tumor studies; not a human cancer efficacy trial.\nEvidence access: Primary abstract\nDietary methionine influences therapy in mouse cancer models and alters human metabolism. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31367041/ · DOI 10.1038/s41586-019-1437-3","model_system":"Patient-derived colorectal xenografts and Kras/Trp53-driven mouse sarcoma; antimetabolite/radiation settings.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d969b004-ccc2-5bb4-9109-8ac649137ad1","stable_key":"import-41a89233-da9a-5b7b-9c18-e19bbadcfe2d","title":"L-Methionine: transport, methylation, sulfur metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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