{"id":"a5f7db5e-754c-5fdc-aff2-70d7d7b285b2","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-scurvy-mucocutaneous-signs","predicate":"dietary_depletion_produces_scurvy_signs","statement":"The four completers developed scurvy; recorded signs included follicular hyperkeratosis, swollen bleeding gums and perifollicular or conjunctival hemorrhage.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"1e12ebf9-38e6-5d80-9119-1f5d87dcb2c6","mechanism_event_label":"Severe shortage became visible in skin, gums and small-vessel bleeding.","subject":{"id":"da1a7137-08f2-5a36-8bb6-377fbd32e327","slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"},"object":{"id":"03ce6fb3-31a4-56e4-99be-484b9ae0f14e","slug":"scurvy-skin-gingival-hemorrhagic-signs","display_name":"Scurvy skin, gum and hemorrhagic signs","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1e12ebf9-38e6-5d80-9119-1f5d87dcb2c6","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-scurvy-mucocutaneous-signs-event","event_type":"observed_intervention","label":"Severe shortage became visible in skin, gums and small-vessel bleeding.","description":"The four completers developed scurvy; recorded signs included follicular hyperkeratosis, swollen bleeding gums and perifollicular or conjunctival hemorrhage.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"da1a7137-08f2-5a36-8bb6-377fbd32e327","slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"03ce6fb3-31a4-56e4-99be-484b9ae0f14e","slug":"scurvy-skin-gingival-hemorrhagic-signs","display_name":"Scurvy skin, gum and hemorrhagic signs","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Historical metabolic-ward study: six apparently healthy male prisoners enrolled, four completed vitamin C deprivation and developed scurvy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Diet devoid of vitamin C but adequate in other essential nutrients.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The human study measured signs, not the contribution of each specific collagen enzyme.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Severe shortage became visible in skin, gums and small-vessel bleeding.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[c-hodges1969] Experimental scurvy in man (1969). https://pubmed.ncbi.nlm.nih.gov/4977512/ DOI: 10.1093/ajcn/22.5.535","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood or whole-person endpoints","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"a73aefe3-a55d-52a3-bbfb-bb14db792c46","evidence_kind":"source_excerpt","locator":"Lines 1493-1503","start_line":1493,"end_line":1503,"excerpt":"### c-scurvy-mucocutaneous-signs\nThe four completers developed scurvy; recorded signs included follicular hyperkeratosis, swollen bleeding gums and perifollicular or conjunctival hemorrhage.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Severe shortage became visible in skin, gums and small-vessel bleeding.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: Historical metabolic-ward study: six apparently healthy male prisoners enrolled, four completed vitamin C deprivation and developed scurvy.\nlimitations: The human study measured signs, not the contribution of each specific collagen enzyme.\nexposure: Diet devoid of vitamin C but adequate in other essential nutrients.\n[c-hodges1969] Experimental scurvy in man (1969). https://pubmed.ncbi.nlm.nih.gov/4977512/ DOI: 10.1093/ajcn/22.5.535","model_system":"Historical metabolic-ward study: six apparently healthy male prisoners enrolled, four completed vitamin C deprivation and developed scurvy.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [c-hodges1969] Experimental scurvy in man (1969). https://pubmed.ncbi.nlm.nih.gov/4977512/ DOI: 10.1093/ajcn/22.5.535","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa811221-13bd-5c10-adc1-eaf097c7703c","stable_key":"import-cb568d28-484a-5c2e-9fcc-2d780358e514","title":"Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b7fd83f956abb81855f2ea23199ba14e465cd91f4a2ac560277ec21ddafd7bfc","revision_id":"6cde9bbb-d712-5746-82a6-85b144253efa","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}