{"id":"a5f497fb-e7f6-5fec-b2eb-15f6082c7798","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-leukemia-mtor","predicate":"loss_reduces","statement":"Slc6a6 loss reduced RAG-GTP-dependent mTOR activation and downstream glycolysis in the mouse leukemia experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"42ccefbc-8d0e-51aa-a8dc-7031952bfecb","mechanism_event_label":"Transport was connected to growth signaling and fuel use.","subject":{"id":"97bfec84-f327-5208-8983-71138dd03b45","slug":"mouse-slc6a6","display_name":"Mouse taurine transporter / Slc6a6","entity_type_key":"protein"},"object":{"id":"6de453cd-ee87-5a7d-9fd1-d7e4d7d46c0d","slug":"mouse-taut-mtor-glycolysis","display_name":"mTOR signaling and glycolysis in mouse taurine-dependent leukemia cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"42ccefbc-8d0e-51aa-a8dc-7031952bfecb","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-leukemia-mtor-event","event_type":"observed_relationship","label":"Transport was connected to growth signaling and fuel use.","description":"Slc6a6 loss reduced RAG-GTP-dependent mTOR activation and downstream glycolysis in the mouse leukemia experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"97bfec84-f327-5208-8983-71138dd03b45","slug":"mouse-slc6a6","display_name":"Mouse taurine transporter / Slc6a6","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6de453cd-ee87-5a7d-9fd1-d7e4d7d46c0d","slug":"mouse-taut-mtor-glycolysis","display_name":"mTOR signaling and glycolysis in mouse taurine-dependent leukemia cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2bf56761-aaca-5d23-aadc-5d1f80178ec4","slug":"mouse-mtor","display_name":"Mouse mechanistic target of rapamycin / Mtor","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ed493ed7-d78c-5509-820a-cb32dd5a1327","slug":"mouse-rraga","display_name":"Mouse Ras-related GTP-binding protein A / Rraga","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text, Figure 5","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse leukemia multiomics, signaling and metabolic experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This pathway is not established as a universal response to taurine in healthy human cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Transport was connected to growth signaling and fuel use.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Taurine from tumour niche drives glycolysis to promote leukaemogenesis. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40369079/ · DOI 10.1038/s41586-025-09018-7","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3a10b148-e63b-5397-8a8b-41f0c021e2c0","evidence_kind":"source_excerpt","locator":"Lines 537-543","start_line":537,"end_line":543,"excerpt":"## taurine-leukemia-mtor\nTransport was connected to growth signaling and fuel use.\nSlc6a6 loss reduced RAG-GTP-dependent mTOR activation and downstream glycolysis in the mouse leukemia experiments.\nModel: Mouse leukemia multiomics, signaling and metabolic experiments.\nLimitations: This pathway is not established as a universal response to taurine in healthy human cells.\nEvidence access: Primary full text, Figure 5\nTaurine from tumour niche drives glycolysis to promote leukaemogenesis. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40369079/ · DOI 10.1038/s41586-025-09018-7","model_system":"Mouse leukemia multiomics, signaling and metabolic experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c6cb77619a374d9b1b04830032fdd3b33d269d160df5baba3778fad5adf57db5","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}