{"id":"a5d70478-cd52-5e0f-92bc-37d7a997746b","stable_key":"182336c6-ed36-5ec6-8a09-25c31096262e:dim-bap-kinetics","predicate":"alters_absorption_profile_of","statement":"DIM delayed the BaP peak and lowered its peak plasma concentration in the microdose study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"638123f7-e8e8-50f0-ab89-b43d5a4bfeb1","mechanism_event_label":"A compound can change absorption timing without proving that enzyme detoxification increased.","subject":{"id":"6009bdd4-f1b5-5867-b5c3-cdf7c9645cd0","slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"},"object":{"id":"3fc35446-c284-5757-bf4b-6af2d3bd8c3e","slug":"benzo-a-pyrene","display_name":"Benzo[a]pyrene","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"638123f7-e8e8-50f0-ab89-b43d5a4bfeb1","stable_key":"182336c6-ed36-5ec6-8a09-25c31096262e:dim-bap-kinetics-event","event_type":"observed_intervention","label":"A compound can change absorption timing without proving that enzyme detoxification increased.","description":"DIM delayed the BaP peak and lowered its peak plasma concentration in the microdose study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e6dbe2ce-de67-5674-bbf2-d3c87515f104","slug":"benzo-a-pyrene-plasma-exposure","display_name":"Plasma benzo[a]pyrene exposure","entity_type_key":"cellular_process"},"role":"measured_endpoint","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6009bdd4-f1b5-5867-b5c3-cdf7c9645cd0","slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"3fc35446-c284-5757-bf4b-6af2d3bd8c3e","slug":"benzo-a-pyrene","display_name":"Benzo[a]pyrene","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/dim-research/36642108.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"93b6510deeea8915ef7bd506c9b7d1d83b8d4b417f3e8194cbb9b33a89233384\", \"start_char\": 0, \"end_char\": 1801, \"text_sha256\": \"93b6510deeea8915ef7bd506c9b7d1d83b8d4b417f3e8194cbb9b33a89233384\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Within-person human dietary intervention and radiotracer microdose","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Seven days of BR-DIM or Brussels sprouts before 50-ng radiolabeled BaP","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Microdose kinetics with large individual variation. Lower plasma radiocarbon does not establish less DNA damage or reduced human cancer risk.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Small adult volunteer cohort","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A compound can change absorption timing without proving that enzyme detoxification increased.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[dim-p36642108] Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or Brussels sprouts. (2023). https://pubmed.ncbi.nlm.nih.gov/36642108/ DOI: 10.1016/j.taap.2023.116377","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Benzo[a]pyrene absorption and metabolism","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4f475d25-e8ec-59c4-b0de-dccda3fe4a78","evidence_kind":"source_excerpt","locator":"Lines 1208-1219","start_line":1208,"end_line":1219,"excerpt":"### dim-bap-kinetics\nDIM delayed the BaP peak and lowered its peak plasma concentration in the microdose study.\nCondition category: normal\nnutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A compound can change absorption timing without proving that enzyme detoxification increased.\norganism: Small adult volunteer cohort\ntissue_or_cell_type: Benzo[a]pyrene absorption and metabolism\nexperimental_model: Within-person human dietary intervention and radiotracer microdose\nlimitations: Microdose kinetics with large individual variation. Lower plasma radiocarbon does not establish less DNA damage or reduced human cancer risk.\nexposure: Seven days of BR-DIM or Brussels sprouts before 50-ng radiolabeled BaP\nevidence_span: {\"source_cache\": \"artifacts/dim-research/36642108.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"93b6510deeea8915ef7bd506c9b7d1d83b8d4b417f3e8194cbb9b33a89233384\", \"start_char\": 0, \"end_char\": 1801, \"text_sha256\": \"93b6510deeea8915ef7bd506c9b7d1d83b8d4b417f3e8194cbb9b33a89233384\"}\n[dim-p36642108] Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or Brussels sprouts. (2023). https://pubmed.ncbi.nlm.nih.gov/36642108/ DOI: 10.1016/j.taap.2023.116377","model_system":"Within-person human dietary intervention and radiotracer microdose","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [dim-p36642108] Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or Brussels sprouts. (2023). https://pubmed.ncbi.nlm.nih.gov/36642108/ DOI: 10.1016/j.taap.2023.116377","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b6d70682-97f9-5893-a03c-f9f88836033c","stable_key":"import-182336c6-ed36-5ec6-8a09-25c31096262e","title":"Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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