{"id":"a5c7edb4-37d4-5a14-8cf3-d0f235a4f994","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-pantethine-human-products","predicate":"administration-yields","statement":"After oral D-pantethine in the four cystinotic children, pantothenic acid and cysteamine appeared as products, while intact pantethine was not detected in plasma.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a911c112-5481-525b-8845-bed3c451a072","mechanism_event_label":"The administered derivative was rapidly converted; the blood exposure was not simply unchanged pantethine.","subject":{"id":"c0600873-c581-5429-91cb-414f179823ce","slug":"pantethine","display_name":"Pantethine","entity_type_key":"small_molecule"},"object":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"a911c112-5481-525b-8845-bed3c451a072","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-pantethine-human-products-event","event_type":"observed_intervention","label":"The administered derivative was rapidly converted; the blood exposure was not simply unchanged pantethine.","description":"After oral D-pantethine in the four cystinotic children, pantothenic acid and cysteamine appeared as products, while intact pantethine was not detected in plasma.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1149e9db-2832-5f4d-aa5b-5aae11bc7788","slug":"cysteamine","display_name":"Cysteamine","entity_type_key":"small_molecule"},"role":"measured hydrolysis-related product","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c0600873-c581-5429-91cb-414f179823ce","slug":"pantethine","display_name":"Pantethine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Pharmacokinetic/metabolic study in four children with nephropathic cystinosis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Historical oral D-pantethine exposures 70–1000 mg/kg/day.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Very high drug-like exposures in a rare disease; not nutritional dosing, ordinary healthy-person pharmacokinetics or proof of the mechanism behind lipid-trial effects. Rat intestinal-enzyme kinetic data in the same paper are not assigned to humans. The primary authors described rapid hydrolysis. This human observation does not by itself specify the reductive/disulfide steps or a human vanin isoform.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The administered derivative was rapidly converted; the blood exposure was not simply unchanged pantethine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-clin-wittwer1985] Metabolism of pantethine in cystinosis. (1985). https://pubmed.ncbi.nlm.nih.gov/4056044/ DOI: 10.1172/jci112152","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma after oral D-pantethine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7c2110ab-8b8f-5326-a11e-f76e56e8784c","evidence_kind":"source_excerpt","locator":"Lines 1467-1479","start_line":1467,"end_line":1479,"excerpt":"### b5-clin-pantethine-human-products\nAfter oral D-pantethine in the four cystinotic children, pantothenic acid and cysteamine appeared as products, while intact pantethine was not detected in plasma.\nCondition category: normal\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The administered derivative was rapidly converted; the blood exposure was not simply unchanged pantethine.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma after oral D-pantethine\nexperimental_model: Pharmacokinetic/metabolic study in four children with nephropathic cystinosis\nlimitations: Very high drug-like exposures in a rare disease; not nutritional dosing, ordinary healthy-person pharmacokinetics or proof of the mechanism behind lipid-trial effects. Rat intestinal-enzyme kinetic data in the same paper are not assigned to humans. The primary authors described rapid hydrolysis. This human observation does not by itself specify the reductive/disulfide steps or a human vanin isoform.\nexposure: Historical oral D-pantethine exposures 70–1000 mg/kg/day.\ncross_nutrient: false\nevidence_location: Primary indexed abstract.\n[b5-clin-wittwer1985] Metabolism of pantethine in cystinosis. (1985). https://pubmed.ncbi.nlm.nih.gov/4056044/ DOI: 10.1172/jci112152","model_system":"Pharmacokinetic/metabolic study in four children with nephropathic cystinosis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b5-clin-wittwer1985] Metabolism of pantethine in cystinosis. (1985). https://pubmed.ncbi.nlm.nih.gov/4056044/ DOI: 10.1172/jci112152","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0716b500-dd0b-5425-b9d0-d88bc9c09e86","stable_key":"import-f992b796-377d-53bf-a39b-7e5d41dbe194","title":"Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b5a49f5a2373ca6064c9a4e014e052dad2f6f199a82bb09b26b82b831c36110b","revision_id":"78f3e793-f084-5ee2-8703-b661c4b650bf","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}