{"id":"a571effa-dd42-5b2b-aef4-d97eb5f32953","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-theanine-headache","predicate":"increases_reported","statement":"Theanine alone increased headache ratings in the acute experiment.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cc218a6d-9cb5-5d8b-8210-fb8eefe916fc","mechanism_event_label":"Unfavorable findings remain visible alongside potential benefits.","subject":{"id":"33a051c5-dba8-53cd-8761-c53732c447e6","slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"},"object":{"id":"bd056977-6388-52c2-83ae-56883e2b6360","slug":"subjective-headache","display_name":"Subjective headache rating","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cc218a6d-9cb5-5d8b-8210-fb8eefe916fc","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-theanine-headache-event","event_type":"observed_intervention","label":"Unfavorable findings remain visible alongside potential benefits.","description":"Theanine alone increased headache ratings in the acute experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"33a051c5-dba8-53cd-8761-c53732c447e6","slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bd056977-6388-52c2-83ae-56883e2b6360","slug":"subjective-headache","display_name":"Subjective headache rating","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/theanine-research/18006208.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"387d341f5aec1fb42bed06021ceb14cc8b49bfdf0f5502284a98806ca732cbdf\", \"start_char\": 0, \"end_char\": 1386, \"text_sha256\": \"387d341f5aec1fb42bed06021ceb14cc8b49bfdf0f5502284a98806ca732cbdf\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind balanced crossover experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"250 mg theanine, 150 mg caffeine, combination and placebo","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Acute effects depend on task and treatment. Benefits of the mixture do not establish synergy for all outcomes or neutralization of caffeine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Theanine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Healthy adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Unfavorable findings remain visible alongside potential benefits.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[theanine-p18006208] The effects of L-theanine, caffeine and their combination on cognition and mood. (2008). https://pubmed.ncbi.nlm.nih.gov/18006208/ DOI: 10.1016/j.biopsycho.2007.09.008","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Cognition and subjective state","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6f503ae8-35d0-52cf-a0f8-6771ff85f169","evidence_kind":"source_excerpt","locator":"Lines 965-976","start_line":965,"end_line":976,"excerpt":"### theanine-theanine-headache\nTheanine alone increased headache ratings in the acute experiment.\nCondition category: normal\nnutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Unfavorable findings remain visible alongside potential benefits.\norganism: Healthy adults\ntissue_or_cell_type: Cognition and subjective state\nexperimental_model: Randomized double-blind balanced crossover experiment\nlimitations: Acute effects depend on task and treatment. Benefits of the mixture do not establish synergy for all outcomes or neutralization of caffeine.\nexposure: 250 mg theanine, 150 mg caffeine, combination and placebo\nevidence_span: {\"source_cache\": \"artifacts/theanine-research/18006208.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"387d341f5aec1fb42bed06021ceb14cc8b49bfdf0f5502284a98806ca732cbdf\", \"start_char\": 0, \"end_char\": 1386, \"text_sha256\": \"387d341f5aec1fb42bed06021ceb14cc8b49bfdf0f5502284a98806ca732cbdf\"}\n[theanine-p18006208] The effects of L-theanine, caffeine and their combination on cognition and mood. (2008). https://pubmed.ncbi.nlm.nih.gov/18006208/ DOI: 10.1016/j.biopsycho.2007.09.008","model_system":"Randomized double-blind balanced crossover experiment","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [theanine-p18006208] The effects of L-theanine, caffeine and their combination on cognition and mood. (2008). https://pubmed.ncbi.nlm.nih.gov/18006208/ DOI: 10.1016/j.biopsycho.2007.09.008","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e2bf3fc8-fc9a-5d50-937a-559a76f8be7d","stable_key":"import-8f12ba85-1a92-5337-a9c0-9cee9b3be90d","title":"L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"c78f2a1961da546cd8d3ae9131a16613aed0d1032904ca19175b0641647142c1","revision_id":"4ec64995-1e5b-5279-9102-f203cb2e29e5","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}