{"id":"a5719690-c4a0-5919-bee0-0b8157c38255","stable_key":"63ce713e-6aea-59f6-9896-ca30e010b2ce:l-tyrosine-renal-production","predicate":"supports","statement":"Stable-isotope studies in 12 healthy adults demonstrated renal phenylalanine-to-tyrosine conversion and net renal tyrosine release.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6aec28f9-289a-5848-9577-14fcaf4a92e4","mechanism_event_label":"The kidney contributes to precursor production as well as filtration.","subject":{"id":"ea908671-6f85-5342-abe4-1a466a3b0572","slug":"pah","display_name":"Human phenylalanine hydroxylase / PAH","entity_type_key":"protein"},"object":{"id":"c9f658b1-4112-5142-a4cb-b272882e317b","slug":"human-renal-phe-tyr-conversion","display_name":"Human renal phenylalanine-to-tyrosine conversion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6aec28f9-289a-5848-9577-14fcaf4a92e4","stable_key":"63ce713e-6aea-59f6-9896-ca30e010b2ce:l-tyrosine-renal-production-event","event_type":"observed_relationship","label":"The kidney contributes to precursor production as well as filtration.","description":"Stable-isotope studies in 12 healthy adults demonstrated renal phenylalanine-to-tyrosine conversion and net renal tyrosine release.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ea908671-6f85-5342-abe4-1a466a3b0572","slug":"pah","display_name":"Human phenylalanine hydroxylase / PAH","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c9f658b1-4112-5142-a4cb-b272882e317b","slug":"human-renal-phe-tyr-conversion","display_name":"Human renal phenylalanine-to-tyrosine conversion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bcfef85f-831d-5439-ba51-1aef4b090441","slug":"l-tyrosine","display_name":"L-Tyrosine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"190407ad-0219-54b5-b05f-7c75f3895ca6","slug":"l-phenylalanine","display_name":"L-Phenylalanine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Arterial/renal-vein tracer sampling; comparison with a separate 12-person splanchnic study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The organ flux measurement is direct; the assignment to PAH is the established reaction, not selective PAH perturbation in this study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Tyrosine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-tyrosine","display_name":"L-Tyrosine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The kidney contributes to precursor production as well as filtration.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The kidney is an important site for in vivo phenylalanine-to-tyrosine conversion in adult humans: A metabolic role of the kidney. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10655515/ · DOI 10.1073/pnas.97.3.1242","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4fa877be-a8c9-5f58-b160-d83dc077eda0","evidence_kind":"source_excerpt","locator":"Lines 20-26","start_line":20,"end_line":26,"excerpt":"## l-tyrosine-renal-production\nThe kidney contributes to precursor production as well as filtration.\nStable-isotope studies in 12 healthy adults demonstrated renal phenylalanine-to-tyrosine conversion and net renal tyrosine release.\nModel: Arterial/renal-vein tracer sampling; comparison with a separate 12-person splanchnic study.\nLimitations: The organ flux measurement is direct; the assignment to PAH is the established reaction, not selective PAH perturbation in this study.\nEvidence access: Primary abstract\nThe kidney is an important site for in vivo phenylalanine-to-tyrosine conversion in adult humans: A metabolic role of the kidney. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10655515/ · DOI 10.1073/pnas.97.3.1242","model_system":"Arterial/renal-vein tracer sampling; comparison with a separate 12-person splanchnic study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"12917df2-c6e0-5b61-850f-dbff6d4b4d30","stable_key":"import-63ce713e-6aea-59f6-9896-ca30e010b2ce","title":"L-Tyrosine: catecholamines, thyroid chemistry, pigment, metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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