{"id":"a517b3af-cf12-5f95-9fbd-7d9c6aa6540d","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-renal-rat-capacity","predicate":"precursor_restriction_increases","statement":"A diet deficient in cysteine and methionine increased the Vmax of the rat high-affinity renal taurine uptake system without changing apparent Km.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"41b8b829-e119-5c88-a7aa-afe2424f37f4","mechanism_event_label":"Conservation involved more transport capacity rather than greater binding affinity.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"b045b376-8752-51bf-9df5-7d753154c5b2","slug":"rat-renal-taurine-conservation","display_name":"Renal taurine conservation in precursor-restricted rats","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"41b8b829-e119-5c88-a7aa-afe2424f37f4","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-renal-rat-capacity-event","event_type":"observed_relationship","label":"Conservation involved more transport capacity rather than greater binding affinity.","description":"A diet deficient in cysteine and methionine increased the Vmax of the rat high-affinity renal taurine uptake system without changing apparent Km.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b045b376-8752-51bf-9df5-7d753154c5b2","slug":"rat-renal-taurine-conservation","display_name":"Renal taurine conservation in precursor-restricted rats","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ca899f13-50ad-55e5-ab99-329ae0038c74","slug":"l-cysteine","display_name":"L-Cysteine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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