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Beta-endorphin did not change, which bears on the common attribution of the mood effect to endorphins.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Three hours after one plunge people felt less bad, though not better, and the endorphin explanation did not hold up.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cold-p37866096] Cardiovascular and mood responses to an acute bout of cold water immersion. (2023). https://pubmed.ncbi.nlm.nih.gov/37866096/ DOI: 10.1016/j.jtherbio.2023.103727","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brachial artery and mood","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f45a82a2-2b4b-5ea4-af0e-ad82a67f2aab","evidence_kind":"source_excerpt","locator":"Lines 741-752","start_line":741,"end_line":752,"excerpt":"### cold-acute-negative-affect\nNegative affect was lower 180 minutes after a single 15-minute immersion at 10 degrees C while positive affect did not change, and cortisol was lower at 180 minutes, whereas serum beta-endorphins did not change throughout the trial.\nCondition category: normal\nnutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.\nplain_language: Three hours after one plunge people felt less bad, though not better, and the endorphin explanation did not hold up.\norganism: Human\ntissue_or_cell_type: Brachial artery and mood\nexperimental_model: Sixteen healthy adults completing one 15-minute immersion at 10 degrees C with Doppler ultrasound and blood sampling\nlimitations: A small single-bout study. Beta-endorphin did not change, which bears on the common attribution of the mood effect to endorphins.\nexposure: One 15-minute immersion at 10 degrees C\nevidence_span: {\"source_cache\": \"artifacts/cold-research/37866096.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2180ef37d9e3dda6b7785769dcc2e4deb89b07a12ffed469e52c80af563cff54\", \"start_char\": 0, \"end_char\": 1665, \"text_sha256\": \"2180ef37d9e3dda6b7785769dcc2e4deb89b07a12ffed469e52c80af563cff54\"}\n[cold-p37866096] Cardiovascular and mood responses to an acute bout of cold water immersion. 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