{"id":"a4792e96-7204-5fb4-8e12-3dc6ba99e7c8","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:cyclosporine-lowers-il2-transcription","predicate":"reduces","statement":"Transcription directed by NFAT is blocked in T cells treated with cyclosporin A, which is why the drug reaches the cytokine genes that coordinate the immune response.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"b7ccca1a-1cd1-5629-844b-6f107ca88540","mechanism_event_label":"Transcription directed by NFAT is blocked in T cells treated with cyclosporin A, which is why the drug reaches the cytokine genes that coordinate the immune response.","subject":{"id":"b199063a-fae6-5c5c-9cb4-22c10453bbac","slug":"cyclosporine","display_name":"Cyclosporine","entity_type_key":"drug"},"object":{"id":"05f8fe57-732f-5d3c-951d-db177b3461c3","slug":"il2-transcription","display_name":"IL2 transcription","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b7ccca1a-1cd1-5629-844b-6f107ca88540","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:cyclosporine-lowers-il2-transcription-event","event_type":"biochemical_relationship","label":"Transcription directed by NFAT is blocked in T cells treated with cyclosporin A, which is why the drug reaches the cytokine genes that coordinate the immune response.","description":"Cytokine gene transcription","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b199063a-fae6-5c5c-9cb4-22c10453bbac","slug":"cyclosporine","display_name":"Cyclosporine","entity_type_key":"drug"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"05f8fe57-732f-5d3c-951d-db177b3461c3","slug":"il2-transcription","display_name":"IL2 transcription","entity_type_key":"cellular_process"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"T lymphocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Cyclosporin A","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The same report records little or no effect on other transcription factors such as AP-1 and NF-kappa B, so this is selectivity for the NFAT route rather than general transcriptional shutdown. AP-1 and NF-kappa B are not recorded as separate entities here because the abstract reports them only as unaffected comparators.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"T lymphocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Transcription directed by NFAT is blocked in T cells treated with cyclosporin A, which is why the drug reaches the cytokine genes that coordinate the immune response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. 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No reference carries a recorded retraction, erratum or expression of concern. Each of the seven is a separate laboratory and each carries its own lineage key, so none of them can be counted twice as independent support. Study-specific concentrations, kinetic constants and limitations retained. Not publisher full text.","file_path":"","sha256":"499d00555a629cba2271c3888d7e93627949891d565c4c78c843610de2913080","revision_id":"263ee68a-4184-51d0-a977-197d7ddb7a4d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}