{"id":"a4590ecd-f234-57b2-9233-b16b5030b461","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:cyclosporine-lowers-renal-trpm6","predicate":"reduces_expression_of","statement":"Cyclosporine significantly decreased renal expression of the magnesium channel TRPM6 in a rat model of cyclosporine nephrotoxicity.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"6778fe84-bdff-5fcb-86df-764f6b21966c","mechanism_event_label":"Cyclosporine significantly decreased renal expression of the magnesium channel TRPM6 in a rat model of cyclosporine nephrotoxicity.","subject":{"id":"b199063a-fae6-5c5c-9cb4-22c10453bbac","slug":"cyclosporine","display_name":"Cyclosporine","entity_type_key":"drug"},"object":{"id":"d73ae2fe-873a-55df-ac69-ee16eea54bd4","slug":"rat-trpm6","display_name":"Rat TRPM6","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"6778fe84-bdff-5fcb-86df-764f6b21966c","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:cyclosporine-lowers-renal-trpm6-event","event_type":"observed_intervention","label":"Cyclosporine significantly decreased renal expression of the magnesium channel TRPM6 in a rat model of cyclosporine nephrotoxicity.","description":"Distal convoluted tubule","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b199063a-fae6-5c5c-9cb4-22c10453bbac","slug":"cyclosporine","display_name":"Cyclosporine","entity_type_key":"drug"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d73ae2fe-873a-55df-ac69-ee16eea54bd4","slug":"rat-trpm6","display_name":"Rat TRPM6","entity_type_key":"protein"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat model of cyclosporine nephrotoxicity","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Cyclosporine, dose and duration not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Rat expression data. The authors read this as the molecular basis of the renal magnesium loss seen in people given cyclosporine, which is a cross-species interpretation and is recorded as one. 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No reference carries a recorded retraction, erratum or expression of concern. Each of the seven is a separate laboratory and each carries its own lineage key, so none of them can be counted twice as independent support. Study-specific concentrations, kinetic constants and limitations retained. Not publisher full text.","file_path":"","sha256":"499d00555a629cba2271c3888d7e93627949891d565c4c78c843610de2913080","revision_id":"263ee68a-4184-51d0-a977-197d7ddb7a4d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}