{"id":"a44e3d9e-f71f-508b-b51e-78c9442f873f","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:fol-elderly-methylation-repletion-null","predicate":"repletion_did_not_significantly_change_assay","statement":"No repletion group showed a significant change from postdepletion methyl-acceptance values over seven weeks.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c289bb36-2a49-5b9b-ae67-f61f7d6d966d","mechanism_event_label":"Returning folate did not quickly normalize this particular readout.","subject":{"id":"e176a266-711e-5469-89da-3fb2d3f244ad","slug":"folate","display_name":"Folate (vitamin B9)","entity_type_key":"chemical_species"},"object":{"id":"9e4efae7-15b8-5735-a045-18c0e733e2dc","slug":"leukocyte-dna-methyl-acceptance","display_name":"Leukocyte DNA methyl-acceptance assay","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c289bb36-2a49-5b9b-ae67-f61f7d6d966d","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:fol-elderly-methylation-repletion-null-event","event_type":"observed_intervention","label":"Returning folate did not quickly normalize this particular readout.","description":"No repletion group showed a significant change from postdepletion methyl-acceptance values over seven weeks.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e176a266-711e-5469-89da-3fb2d3f244ad","slug":"folate","display_name":"Folate (vitamin B9)","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9e4efae7-15b8-5735-a045-18c0e733e2dc","slug":"leukocyte-dna-methyl-acceptance","display_name":"Leukocyte DNA methyl-acceptance assay","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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