{"id":"a41d0107-1739-5a8d-b7c5-744ff359829d","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-f1-binding","predicate":"binds_and_inhibits","statement":"The bovine F1-ATPase crystal structure placed resveratrol in a pocket between the gamma tip and beta-TP subunit at the rotary bearing.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"d051bdf7-0c54-5f74-9a87-3b87676ee729","mechanism_event_label":"Binding can obstruct the rotary machinery for energy conversion.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"08f6ad83-c6f4-5645-a971-e1991fc0956e","slug":"bovine-f1-atpase","display_name":"Bovine mitochondrial F1-ATPase","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"d051bdf7-0c54-5f74-9a87-3b87676ee729","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-f1-binding-event","event_type":"observed_relationship","label":"Binding can obstruct the rotary machinery for energy conversion.","description":"The bovine F1-ATPase crystal structure placed resveratrol in a pocket between the gamma tip and beta-TP subunit at the rotary bearing.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"08f6ad83-c6f4-5645-a971-e1991fc0956e","slug":"bovine-f1-atpase","display_name":"Bovine mitochondrial F1-ATPase","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"58b974f1-d389-5bf6-81cd-889c44442c42","slug":"atp","display_name":"ATP","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"136c3764-1b93-5f79-8673-9001cab9bc3d","slug":"adp","display_name":"Adenosine diphosphate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Isolated bovine heart F1 structures and inhibition study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The proposed block of rotation explains inhibition; the structure does not establish human tissue ATP loss after oral intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Binding can obstruct the rotary machinery for energy conversion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17698806/ · DOI 10.1073/pnas.0706290104","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8ac50533-d665-56ea-a429-010dda510a7f","evidence_kind":"source_excerpt","locator":"Lines 142-148","start_line":142,"end_line":148,"excerpt":"## resveratrol-f1-binding\nBinding can obstruct the rotary machinery for energy conversion.\nThe bovine F1-ATPase crystal structure placed resveratrol in a pocket between the gamma tip and beta-TP subunit at the rotary bearing.\nModel: Isolated bovine heart F1 structures and inhibition study.\nLimitations: The proposed block of rotation explains inhibition; the structure does not establish human tissue ATP loss after oral intake.\nEvidence access: Primary abstract\nMechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17698806/ · DOI 10.1073/pnas.0706290104","model_system":"Isolated bovine heart F1 structures and inhibition study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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