{"id":"a4105e34-5ce0-5c2e-863c-104db6796d60","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-lps-reduces-rbp-transcript","predicate":"inflammation_reduces","statement":"Inflammation reduced hepatic RBP mRNA and circulating transport proteins in the same rat study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0bb9b392-e498-5f5c-be26-844c5161d7f6","mechanism_event_label":"Transport regulation helps explain why blood retinol can fall during illness.","subject":{"id":"e96aad69-74fb-55c6-8378-7d5c281003eb","slug":"lipopolysaccharide","display_name":"Lipopolysaccharide","entity_type_key":"chemical_species"},"object":{"id":"b42cfa23-b7a2-52a0-aaaa-dea49dbb21db","slug":"rbp4-mrna","display_name":"RBP4 mRNA","entity_type_key":"rna"},"evidence_count":1,"mechanism_event":{"id":"0bb9b392-e498-5f5c-be26-844c5161d7f6","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-lps-reduces-rbp-transcript-event","event_type":"biochemical_relationship","label":"Transport regulation helps explain why blood retinol can fall during illness.","description":"Inflammation reduced hepatic RBP mRNA and circulating transport proteins in the same rat study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2166313e-8877-585f-8594-c8813793c5ed","slug":"rbp4","display_name":"Retinol-binding protein 4 / RBP4","entity_type_key":"protein"},"role":"carrier_identity","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8124a8cb-9669-5050-ba1d-b022d7f3beb5","slug":"ttr","display_name":"Transthyretin / TTR","entity_type_key":"protein"},"role":"carrier_identity","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"148c57d8-c658-5769-89e8-1194cef2a782","slug":"retinol","display_name":"All-trans-retinol","entity_type_key":"small_molecule"},"role":"transported_retinoid","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e96aad69-74fb-55c6-8378-7d5c281003eb","slug":"lipopolysaccharide","display_name":"Lipopolysaccharide","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"b42cfa23-b7a2-52a0-aaaa-dea49dbb21db","slug":"rbp4-mrna","display_name":"RBP4 mRNA","entity_type_key":"rna"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [va-rosales1996] Effects of acute inflammation on plasma retinol, retinol-binding protein, and its mRNA in the liver and kidneys of vitamin A-sufficient rats (1996). https://pubmed.ncbi.nlm.nih.gov/8725149/ DOI: 10.1016/s0022-2275(20)42007-3","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}