{"id":"a3e72e08-ad0b-55e4-9fa4-48e7ea80efdf","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-deficiency-ferroportin-transcript","predicate":"deficiency_reduces","statement":"Vitamin A deficiency reduced intestinal Fpn1 transcripts in the same rat study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"308512df-445c-5341-b514-986c77b081d9","mechanism_event_label":"Expression of an iron-export component changed alongside systemic signals.","subject":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"object":{"id":"23c2ae0a-6485-5dea-8375-987eefcab18c","slug":"slc40a1-mrna","display_name":"SLC40A1 mRNA","entity_type_key":"rna"},"evidence_count":1,"mechanism_event":{"id":"308512df-445c-5341-b514-986c77b081d9","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-deficiency-ferroportin-transcript-event","event_type":"biochemical_relationship","label":"Expression of an iron-export component changed alongside systemic signals.","description":"Vitamin A deficiency reduced intestinal Fpn1 transcripts in the same rat study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2210be14-d81c-5a26-a3fb-5b566f47f1fd","slug":"slc40a1","display_name":"Ferroportin / SLC40A1","entity_type_key":"protein"},"role":"protein_identity","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"transported_nutrient","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"23c2ae0a-6485-5dea-8375-987eefcab18c","slug":"slc40a1-mrna","display_name":"SLC40A1 mRNA","entity_type_key":"rna"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [va-cunha2016] Vitamin A deficiency modulates iron metabolism independent of hemojuvelin (Hfe2) and bone morphogenetic protein 6 (Bmp6) transcript levels (2016). https://pubmed.ncbi.nlm.nih.gov/27551308/ DOI: 10.1186/s12263-016-0519-4","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}