{"id":"a284212f-6576-5d22-b54c-97592fe2c6c0","stable_key":"a9dd23c6-978a-5755-8bd8-f29bd1fe0cda:nia-clin-pellagra-riboflavin-context","predicate":"shortage_injures_despite_other_b_vitamins","statement":"Cheilosis and angular stomatitis occurred during the low-niacin/tryptophan regimen even with approximately 2 mg/day total riboflavin and supplemental pyridoxine; these lesions were not specific evidence of B2 deficiency.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7f23b656-155e-56aa-be43-075e3474d708","mechanism_event_label":"A sore mouth can arise from different nutrient problems. The appearance alone did not identify which vitamin was lacking.","subject":{"id":"dfc664d3-d84d-55ca-afe2-1abbfafd83a7","slug":"niacin","display_name":"Niacin (vitamin B3)","entity_type_key":"nutrient_element"},"object":{"id":"a30b637c-4c77-5fff-9032-7262339f152c","slug":"niacin-related-oral-mucosal-injury","display_name":"Niacin-related oral mucosal injury","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7f23b656-155e-56aa-be43-075e3474d708","stable_key":"a9dd23c6-978a-5755-8bd8-f29bd1fe0cda:nia-clin-pellagra-riboflavin-context-event","event_type":"observed_intervention","label":"A sore mouth can arise from different nutrient problems. The appearance alone did not identify which vitamin was lacking.","description":"Cheilosis and angular stomatitis occurred during the low-niacin/tryptophan regimen even with approximately 2 mg/day total riboflavin and supplemental pyridoxine; these lesions were not specific evidence of B2 deficiency.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"86eb1eee-a8d1-539c-8c17-0911f69b6f1b","slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"},"role":"supplied_co_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"aa6648f2-8962-5567-9939-ef4145e40ed1","slug":"pyridoxine","display_name":"Pyridoxine","entity_type_key":"small_molecule"},"role":"supplied_co_nutrient","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"dfc664d3-d84d-55ca-afe2-1abbfafd83a7","slug":"niacin","display_name":"Niacin (vitamin B3)","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a30b637c-4c77-5fff-9032-7262339f152c","slug":"niacin-related-oral-mucosal-injury","display_name":"Niacin-related oral mucosal injury","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Riboflavin (vitamin B2) (supplied_co_nutrient); Pyridoxine (supplied_co_nutrient)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/niacin-clinical-sources/goldsmith1952.txt\", \"locator\": \"Primary full report; exact character range, zero-based and end-exclusive\", \"file_sha256\": \"2d4004fb5985f80c8e44909506e1aa05b6eefd838f4c28102beac30fb3092bc5\", \"start_char\": 15452, \"end_char\": 16019, \"text_sha256\": \"66c68d7739e59c3e98f30fe0757f468a7952746f7dfe082138dfa6727fa54bf4\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Historical metabolic-ward restriction; seven women, with three prolonged corn-diet cases developing pellagra","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Corn diet about 4.7 mg niacin and 190 mg tryptophan/day; other B-vitamin supplements; 40–135 days depending on subject; subsequent niacinamide or DL-tryptophan","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Very small nonrandomized historical experiment. Diets and exposure durations differed; signs were not universal. Nitrogen balance did not prove niacin sufficiency. This does not establish a modern intake threshold or demonstrate a corn toxin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Niacin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"niacin","display_name":"Niacin (vitamin B3)","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A sore mouth can arise from different nutrient problems. The appearance alone did not identify which vitamin was lacking.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[nia-clin-goldsmith1952] Studies of niacin requirement in man. I. Experimental pellagra in subjects on corn diets low in niacin and tryptophan. 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The appearance alone did not identify which vitamin was lacking.\norganism: Homo sapiens\ntissue_or_cell_type: Skin, oral and intestinal mucosa\nexperimental_model: Historical metabolic-ward restriction; seven women, with three prolonged corn-diet cases developing pellagra\nlimitations: Very small nonrandomized historical experiment. Diets and exposure durations differed; signs were not universal. Nitrogen balance did not prove niacin sufficiency. This does not establish a modern intake threshold or demonstrate a corn toxin.\nexposure: Corn diet about 4.7 mg niacin and 190 mg tryptophan/day; other B-vitamin supplements; 40–135 days depending on subject; subsequent niacinamide or DL-tryptophan\ncross_nutrient: Riboflavin (vitamin B2) (supplied_co_nutrient); Pyridoxine (supplied_co_nutrient)\nevidence_span: {\"source_cache\": \"artifacts/niacin-clinical-sources/goldsmith1952.txt\", \"locator\": \"Primary full report; exact character range, zero-based and end-exclusive\", \"file_sha256\": \"2d4004fb5985f80c8e44909506e1aa05b6eefd838f4c28102beac30fb3092bc5\", \"start_char\": 15452, \"end_char\": 16019, \"text_sha256\": \"66c68d7739e59c3e98f30fe0757f468a7952746f7dfe082138dfa6727fa54bf4\"}\nsupplementary_evidence_spans: [{\"source_cache\": \"artifacts/niacin-clinical-sources/goldsmith1952.txt\", \"start_char\": 8901, \"end_char\": 9290, \"file_sha256\": \"2d4004fb5985f80c8e44909506e1aa05b6eefd838f4c28102beac30fb3092bc5\", \"text_sha256\": \"59d1a659822aca95688b5e36bd07b41ea700bfbfdc92b40005acf11bd540b046\", \"locator\": \"Methods: supplied B-vitamin quantities\"}, {\"source_cache\": \"artifacts/niacin-clinical-sources/goldsmith1952.txt\", \"start_char\": 31540, \"end_char\": 31811, \"file_sha256\": \"2d4004fb5985f80c8e44909506e1aa05b6eefd838f4c28102beac30fb3092bc5\", \"text_sha256\": \"ff226f4114a9dec08a00118aa9df933b8246dc89bcf362b2569c089b511d9d3e\", \"locator\": \"Discussion: riboflavin and pyridoxine supplements\"}]\n[nia-clin-goldsmith1952] Studies of niacin requirement in man. 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