{"id":"a25376bf-cdda-5e75-923f-e8259c5e4f0b","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-relax-caffeine","predicate":"increases","statement":"Three days of caffeine 5 mg/kg/day prolonged relaxation time by about 10%; acute caffeine and the creatine/caffeine combination did not significantly change it.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"3d640194-5156-57ca-8cdf-4698dc0d4a5f","mechanism_event_label":"Repeated and single-dose caffeine did not have the same measured effect.","subject":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"object":{"id":"948a9644-3011-5f27-9b89-6a4d11d978ac","slug":"quadriceps-relaxation-time","display_name":"Electrically evoked quadriceps relaxation time","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3d640194-5156-57ca-8cdf-4698dc0d4a5f","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-relax-caffeine-event","event_type":"observed_relationship","label":"Repeated and single-dose caffeine did not have the same measured effect.","description":"Three days of caffeine 5 mg/kg/day prolonged relaxation time by about 10%; acute caffeine and the creatine/caffeine combination did not significantly change it.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"948a9644-3011-5f27-9b89-6a4d11d978ac","slug":"quadriceps-relaxation-time","display_name":"Electrically evoked quadriceps relaxation time","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same ten-man muscle-stimulation experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Relaxation is a candidate explanation for performance differences, not proof of a universal creatine interaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Repeated and single-dose caffeine did not have the same measured effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Opposite actions of caffeine and creatine on muscle relaxation time in humans. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11796658/ · DOI 10.1152/japplphysiol.00255.2001","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"607b0f11-dc03-5ac5-a356-4a5050b8a978","evidence_kind":"source_excerpt","locator":"Lines 468-474","start_line":468,"end_line":474,"excerpt":"## caf-relax-caffeine\nRepeated and single-dose caffeine did not have the same measured effect.\nThree days of caffeine 5 mg/kg/day prolonged relaxation time by about 10%; acute caffeine and the creatine/caffeine combination did not significantly change it.\nModel: Same ten-man muscle-stimulation experiment.\nLimitations: Relaxation is a candidate explanation for performance differences, not proof of a universal creatine interaction.\nEvidence access: Primary abstract\nOpposite actions of caffeine and creatine on muscle relaxation time in humans. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11796658/ · DOI 10.1152/japplphysiol.00255.2001","model_system":"Same ten-man muscle-stimulation experiment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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