{"id":"a2171e58-69fc-5e99-80ea-ac52ae7fb07f","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-agmat-taurocyamine","predicate":"hydrolyzes","statement":"Human AGMAT R105 hydrolyzed taurocyamine more efficiently than guanidinobutyrate in the tested concentration range; R105 and G105 differed in substrate preferences.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0abea6e5-2f3f-5a4c-9445-3eaf8e1a8909","mechanism_event_label":"A variant can alter which related metabolic pool is processed.","subject":{"id":"bba88813-506c-5bbf-b85e-fc33beefc748","slug":"agmat","display_name":"Human AGMAT, guanidino acid hydrolase candidate / historically annotated agmatinase","entity_type_key":"protein"},"object":{"id":"8a2c2166-001d-5945-ac81-a303d5795133","slug":"taurocyamine","display_name":"Taurocyamine / guanidinotaurine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"0abea6e5-2f3f-5a4c-9445-3eaf8e1a8909","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-agmat-taurocyamine-event","event_type":"observed_relationship","label":"A variant can alter which related metabolic pool is processed.","description":"Human AGMAT R105 hydrolyzed taurocyamine more efficiently than guanidinobutyrate in the tested concentration range; R105 and G105 differed in substrate preferences.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bba88813-506c-5bbf-b85e-fc33beefc748","slug":"agmat","display_name":"Human AGMAT, guanidino acid hydrolase candidate / historically annotated agmatinase","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8a2c2166-001d-5945-ac81-a303d5795133","slug":"taurocyamine","display_name":"Taurocyamine / guanidinotaurine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ae2dddf4-ce04-57e3-8a06-7ed9fdc24554","slug":"agmatine-sulfate","display_name":"Agmatine Sulfate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e2f83eb4-99ed-5050-87d3-3e4701d05c1a","slug":"agmatine","display_name":"Agmatine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"37cf0152-db25-5773-a726-d0c0facb2e24","slug":"urea","display_name":"Urea","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text; Figures 2 and 3","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified human variants; 10 mM substrate comparison and concentration series.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This does not establish a clinically meaningful taurine deficit or a supplementation response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Agmatine Sulfate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"agmatine-sulfate","display_name":"Agmatine Sulfate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A variant can alter which related metabolic pool is processed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Guanidino acid hydrolysis by the human enzyme annotated as agmatinase. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36543883/ · DOI 10.1038/s41598-022-26655-4","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"43281ff0-ac8d-50fd-851f-a9c4f0b6f426","evidence_kind":"source_excerpt","locator":"Lines 132-138","start_line":132,"end_line":138,"excerpt":"## agmatine-sulfate-agmat-taurocyamine\nA variant can alter which related metabolic pool is processed.\nHuman AGMAT R105 hydrolyzed taurocyamine more efficiently than guanidinobutyrate in the tested concentration range; R105 and G105 differed in substrate preferences.\nModel: Purified human variants; 10 mM substrate comparison and concentration series.\nLimitations: This does not establish a clinically meaningful taurine deficit or a supplementation response.\nEvidence access: Primary full text; Figures 2 and 3\nGuanidino acid hydrolysis by the human enzyme annotated as agmatinase. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36543883/ · DOI 10.1038/s41598-022-26655-4","model_system":"Purified human variants; 10 mM substrate comparison and concentration series.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e0426971-7d13-51c9-8354-6547b664f1cf","stable_key":"import-220adaab-10d8-5c4e-a3f5-a48700ea794d","title":"Agmatine Sulfate: transport, guanidino metabolism, ion channels and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b55d70e22d07b80964f825770d92fdd1745221420ed8af8d94ca5182b9994509","revision_id":"fc7be029-20e0-5943-b74e-3b06ba694571","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}