{"id":"a1fca92b-6d28-5e46-8dc6-14fd427e54e2","stable_key":"1fb6218a-60d1-55ea-87fe-07d15d0fc46f:statin-reduces-rho-gtpase-prenylation","predicate":"reduces","statement":"Statin treatment reduced host protein prenylation including prenylation of Rho GTPases, and reduced respiratory syncytial virus infection in vitro through combined cholesterol and isoprenoid effects.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"94ae4eac-3ad8-5dd5-abd7-2cf46931c099","mechanism_event_label":"Statin treatment reduced host protein prenylation including prenylation of Rho GTPases, and reduced respiratory syncytial virus infection in vitro through combined cholesterol and isoprenoid effects.","subject":{"id":"4c58906d-dbdd-5b59-9849-3f26f120062e","slug":"statin-therapy","display_name":"Statin therapy as a drug class","entity_type_key":"chemical_species"},"object":{"id":"2ad6c0a7-3e19-57ac-a3f1-04b0c02e4d19","slug":"rho-gtpase-prenylation","display_name":"Prenylation of Rho-family GTPases","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"94ae4eac-3ad8-5dd5-abd7-2cf46931c099","stable_key":"1fb6218a-60d1-55ea-87fe-07d15d0fc46f:statin-reduces-rho-gtpase-prenylation-event","event_type":"observed_relationship","label":"Statin treatment reduced host protein prenylation including prenylation of Rho GTPases, and reduced respiratory syncytial virus infection in vitro through combined cholesterol and isoprenoid effects.","description":"Statin treatment reduced host protein prenylation including prenylation of Rho GTPases, and reduced respiratory syncytial virus infection in vitro through combined cholesterol and isoprenoid effects.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4c58906d-dbdd-5b59-9849-3f26f120062e","slug":"statin-therapy","display_name":"Statin therapy as a drug class","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2ad6c0a7-3e19-57ac-a3f1-04b0c02e4d19","slug":"rho-gtpase-prenylation","display_name":"Prenylation of Rho-family GTPases","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7e6d85c1-25b7-549b-9883-8e9d5d11ae3d","slug":"geranylgeranyl-diphosphate","display_name":"Geranylgeranyl diphosphate / GGPP","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8a96d7c7-d28d-5615-94a7-3c397bed8f9d","slug":"rac1","display_name":"RAC1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Live-cell high-content screen in human cell culture","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Statins, and separately perillyl alcohol as a geranylgeranyltransferase inhibitor","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The screen tested statins as a class without attributing the result to atorvastatin, and respiratory syncytial virus infection itself globally upregulated prenylation, so the baseline was not a resting cell.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Live-cell high-content screen in human cell culture","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Statin treatment reduced host protein prenylation including prenylation of Rho GTPases, and reduced respiratory syncytial virus infection in vitro through combined cholesterol and isoprenoid effects.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection. (2021). https://pubmed.ncbi.nlm.nih.gov/34716403/ DOI: 10.1038/s42003-021-02754-2","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Host protein prenylation and virus production","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"21352be3-7ea5-526a-ac60-ef337d2e5b14","evidence_kind":"source_excerpt","locator":"Lines 89-98","start_line":89,"end_line":98,"excerpt":"## statin-reduces-rho-gtpase-prenylation\nStatin treatment reduced host protein prenylation including prenylation of Rho GTPases, and reduced respiratory syncytial virus infection in vitro through combined cholesterol and isoprenoid effects.\nModel/species: Live-cell high-content screen in human cell culture\nTissue/system: Host protein prenylation and virus production\nExposure: Statins, and separately perillyl alcohol as a geranylgeranyltransferase inhibitor\nRoute: In vitro\nDuration: Not stated here\nLimits: The screen tested statins as a class without attributing the result to atorvastatin, and respiratory syncytial virus infection itself globally upregulated prenylation, so the baseline was not a resting cell.\nPrimary reference: Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection. (2021). https://pubmed.ncbi.nlm.nih.gov/34716403/ DOI: 10.1038/s42003-021-02754-2\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"a4431d8c-34d7-5db7-9edf-a35f68feba39","stable_key":"import-1fb6218a-60d1-55ea-87fe-07d15d0fc46f","title":"Atorvastatin: mechanism of action from target occupancy to isoprenoids, transport, muscle and metabolism (2026-09-22)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twelve primary studies resolved by PubMed title search and cross-checked against live PubMed metadata. Findings obtained with mevastatin, simvastatin or the statin class are recorded against those subjects. Study-specific citations, doses, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"6307f1acf99f90662320328974781ee660348754257b1e1555701ad597edc8e5","revision_id":"447c5978-ba3f-58fe-ac85-664caa72e01b","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}