{"id":"a1e11a4a-c8d2-5bb7-a7ca-4287cc167699","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-restriction-human-metabolome","predicate":"changes_tested","statement":"A controlled human feeding component changed systemic metabolism in directions overlapping the mouse experiments.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"393d398b-9cf1-5176-b42c-82b220b6e446","mechanism_event_label":"Human metabolic feasibility was tested separately from tumor treatment.","subject":{"id":"2fa490e6-50cc-5a22-b1ea-af5e128666e4","slug":"experimental-methionine-restriction","display_name":"Experimentally methionine-restricted diet","entity_type_key":"cellular_process"},"object":{"id":"256e1f31-9646-5cde-83fb-db4398f68dcf","slug":"human-controlled-methionine-restriction-metabolome","display_name":"Human systemic metabolome during controlled methionine restriction","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"393d398b-9cf1-5176-b42c-82b220b6e446","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-restriction-human-metabolome-event","event_type":"observed_relationship","label":"Human metabolic feasibility was tested separately from tumor treatment.","description":"A controlled human feeding component changed systemic metabolism in directions overlapping the mouse experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2fa490e6-50cc-5a22-b1ea-af5e128666e4","slug":"experimental-methionine-restriction","display_name":"Experimentally methionine-restricted diet","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"256e1f31-9646-5cde-83fb-db4398f68dcf","slug":"human-controlled-methionine-restriction-metabolome","display_name":"Human systemic metabolome during controlled methionine restriction","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Small controlled human feeding study alongside animal cancer experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No cancer response or survival benefit was demonstrated in the human feeding component.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Methionine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Human metabolic feasibility was tested separately from tumor treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Dietary methionine influences therapy in mouse cancer models and alters human metabolism. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31367041/ · DOI 10.1038/s41586-019-1437-3","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cd3143ec-40eb-5bfa-bc73-3306f62e1f2f","evidence_kind":"source_excerpt","locator":"Lines 492-498","start_line":492,"end_line":498,"excerpt":"## methionine-restriction-human-metabolome\nHuman metabolic feasibility was tested separately from tumor treatment.\nA controlled human feeding component changed systemic metabolism in directions overlapping the mouse experiments.\nModel: Small controlled human feeding study alongside animal cancer experiments.\nLimitations: No cancer response or survival benefit was demonstrated in the human feeding component.\nEvidence access: Primary abstract\nDietary methionine influences therapy in mouse cancer models and alters human metabolism. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31367041/ · DOI 10.1038/s41586-019-1437-3","model_system":"Small controlled human feeding study alongside animal cancer experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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