{"id":"a1a340e8-7c02-5ccd-80d9-7637221e46a0","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-xo-sulfate-6-mercaptopurine","predicate":"inhibits","statement":"Myricetin 3′-O-sulfate inhibited bovine-milk xanthine oxidase-mediated 6-mercaptopurine oxidation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f4b73295-a637-598e-bea0-b8a7a818a9c1","mechanism_event_label":"One enzyme processes both a natural purine and a medication.","subject":{"id":"b71fca58-3e61-5eed-bfa5-4465fcc9407e","slug":"myricetin-3-prime-o-sulfate","display_name":"Myricetin 3′-O-sulfate","entity_type_key":"small_molecule"},"object":{"id":"8f0bfaa1-4efc-586c-bbf9-764de45f4d91","slug":"bovine-xdh","display_name":"Bovine xanthine oxidoreductase / XDH","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"f4b73295-a637-598e-bea0-b8a7a818a9c1","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-xo-sulfate-6-mercaptopurine-event","event_type":"observed_relationship","label":"One enzyme processes both a natural purine and a medication.","description":"Myricetin 3′-O-sulfate inhibited bovine-milk xanthine oxidase-mediated 6-mercaptopurine oxidation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b71fca58-3e61-5eed-bfa5-4465fcc9407e","slug":"myricetin-3-prime-o-sulfate","display_name":"Myricetin 3′-O-sulfate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8f0bfaa1-4efc-586c-bbf9-764de45f4d91","slug":"bovine-xdh","display_name":"Bovine xanthine oxidoreductase / XDH","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"deeef9b0-5e9b-5570-b893-5c677fd5c52a","slug":"6-mercaptopurine","display_name":"6-Mercaptopurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract and repository full-text methods","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified bovine-milk enzyme, chromatographic product analysis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Sulfate was more potent than parent in the study. Not demonstrated human urate lowering or thiopurine toxicity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"One enzyme processes both a natural purine and a medication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Inhibition of xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation by luteolin, naringenin, myricetin, ampelopsin and their conjugated metabolites. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37734263/ · DOI 10.1016/j.biopha.2023.115548","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"86e83a39-aa8f-58be-9485-05031a3b6aac","evidence_kind":"source_excerpt","locator":"Lines 412-418","start_line":412,"end_line":418,"excerpt":"## myricetin-xo-sulfate-6-mercaptopurine\nOne enzyme processes both a natural purine and a medication.\nMyricetin 3′-O-sulfate inhibited bovine-milk xanthine oxidase-mediated 6-mercaptopurine oxidation.\nModel: Purified bovine-milk enzyme, chromatographic product analysis.\nLimitations: Sulfate was more potent than parent in the study. Not demonstrated human urate lowering or thiopurine toxicity.\nEvidence access: Primary abstract and repository full-text methods\nInhibition of xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation by luteolin, naringenin, myricetin, ampelopsin and their conjugated metabolites. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37734263/ · DOI 10.1016/j.biopha.2023.115548","model_system":"Purified bovine-milk enzyme, chromatographic product analysis.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0abf512275cf3aae9e4ec8544f1cde97e0155d0cfb5be12a193cdd5a898386a7","revision_id":"422e342f-a55c-5e73-ba98-43df560f49b9","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}