{"id":"a10a83d2-ef13-558f-9d83-5b8ef6dee28c","stable_key":"4fef8d72-f107-5eb5-b2fb-483ca85465e0:k2-mk7-persistence","predicate":"has_greater_persistence_than","statement":"MK-7 showed more stable serum levels and seven- to eightfold higher accumulation during repeated intake than K1 in the comparison.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d22f9ed2-b800-5c71-b37e-bacd39d23f84","mechanism_event_label":"Different vitamin K forms have different blood-exposure profiles.","subject":{"id":"a3ff2a7b-69f3-5098-8fac-fb8d7668397b","slug":"menaquinone-7","display_name":"Menaquinone-7 / MK-7","entity_type_key":"small_molecule"},"object":{"id":"5f9fd13b-5428-5024-a855-9db526855890","slug":"phylloquinone","display_name":"Phylloquinone","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"d22f9ed2-b800-5c71-b37e-bacd39d23f84","stable_key":"4fef8d72-f107-5eb5-b2fb-483ca85465e0:k2-mk7-persistence-event","event_type":"observed_intervention","label":"Different vitamin K forms have different blood-exposure profiles.","description":"MK-7 showed more stable serum levels and seven- to eightfold higher accumulation during repeated intake than K1 in the comparison.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a3ff2a7b-69f3-5098-8fac-fb8d7668397b","slug":"menaquinone-7","display_name":"Menaquinone-7 / MK-7","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5f9fd13b-5428-5024-a855-9db526855890","slug":"phylloquinone","display_name":"Phylloquinone","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/k2-research/17158229.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1bf2196600220143fbc5ba85e8aba71b4c8aa931f4a6c47545c3db9570283faf\", \"start_char\": 0, \"end_char\": 1248, \"text_sha256\": \"1bf2196600220143fbc5ba85e8aba71b4c8aa931f4a6c47545c3db9570283faf\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Comparative human absorption and activity experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Phylloquinone versus natto-derived MK-7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Biochemical exposure and activity endpoints, not fracture or cardiovascular-event prevention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"k2","display_name":"Vitamin K2 / menaquinone family","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Healthy volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Different vitamin K forms have different blood-exposure profiles.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k2-p17158229] Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. (2007). https://pubmed.ncbi.nlm.nih.gov/17158229/ DOI: 10.1182/blood-2006-08-040709","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum vitamers and osteocalcin","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2fd1a86c-d502-51cc-bffb-51e36feabeba","evidence_kind":"source_excerpt","locator":"Lines 292-303","start_line":292,"end_line":303,"excerpt":"### k2-mk7-persistence\nMK-7 showed more stable serum levels and seven- to eightfold higher accumulation during repeated intake than K1 in the comparison.\nCondition category: normal\nnutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Different vitamin K forms have different blood-exposure profiles.\norganism: Healthy volunteers\ntissue_or_cell_type: Serum vitamers and osteocalcin\nexperimental_model: Comparative human absorption and activity experiments\nlimitations: Biochemical exposure and activity endpoints, not fracture or cardiovascular-event prevention.\nexposure: Phylloquinone versus natto-derived MK-7\nevidence_span: {\"source_cache\": \"artifacts/k2-research/17158229.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1bf2196600220143fbc5ba85e8aba71b4c8aa931f4a6c47545c3db9570283faf\", \"start_char\": 0, \"end_char\": 1248, \"text_sha256\": \"1bf2196600220143fbc5ba85e8aba71b4c8aa931f4a6c47545c3db9570283faf\"}\n[k2-p17158229] Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. (2007). https://pubmed.ncbi.nlm.nih.gov/17158229/ DOI: 10.1182/blood-2006-08-040709","model_system":"Comparative human absorption and activity experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [k2-p17158229] Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. (2007). https://pubmed.ncbi.nlm.nih.gov/17158229/ DOI: 10.1182/blood-2006-08-040709","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dfeae572-af3d-5042-a10e-e67596f9ab28","stable_key":"import-4fef8d72-f107-5eb5-b2fb-483ca85465e0","title":"Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"dc31aff21110d09b025c177e03b4c5ca8349d52bf5f962285fdbfcf660c0e4f6","revision_id":"850887db-34f6-55aa-9d3e-b8fd3a4a5de3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}